Showing papers in "Advanced Drug Delivery Reviews in 1990"

TL;DR: Methods for delivering functional non-replicating plasmids in vivo without the use of retroviruses are currently in their infancy; however, the data indicate that direct delivery and in vivo expression of genes are possible.

TL;DR: A review of topically applied liposomal formulations with emphasis on the evaluation ofliposomal systems in a wide variety of animal models and human skin using both in-vivo and in-Vitro techniques is presented.

TL;DR: This review presents the current status of drug delivery systems based on parenteral emulsions, and future trends in this field are outlined, followed by a discussion of potential pitfalls in the evaluation of novel emulsion delivery systems.

TL;DR: It must be concluded that in certain circumstances intestinal translocation of particulates is possible and it is possible that particulate carriers can be exploited successfully to develop more effective oral vaccines for non-replicating antigens.

TL;DR: Inhalation offers some exciting possibilities for the delivery of new generation products of biotechnology like polypeptides and proteins, but the dependence of lung metabolism and absorption upon molecular structure is poorly understood and requires further research.

TL;DR: This paper reviews the available data pertaining to the disposition and fate of liposomes in the lungs of laboratory animals as well as of man and examines the pharmacokinetics of the solutes or measured pharmacological responses following pulmonary administration.

TL;DR: Both reduced toxicity and increased efficiency were reported in experimental animal models and encouraging results were obtained concerning the possibility to overcome multidrug resistance with these nanoparticles.

TL;DR: Because (modified) lipoproteins can be taken up by specific receptors on tumor cells or liver cells they are attractive potential carriers of (pro)drugs to these cell types.

TL;DR: The principal types of erodible polymers useful for delivery of macromolecules include poly(α-hydroxy acids), crosslinked polyester hydrogels, poly(orthoesters), polyanhydrides and polypeptides.

TL;DR: The lung has a range of enzyme systems and the potential to metabolize a broad variety of xenobiotics, which may result in first-pass elimination of drugs administered via the airways and may contribute to the clearance of systemically circulating compounds.

TL;DR: The question of which strategies should be used to obtain protein molecules exhibiting the best qualities, with enhanced stability being a primary goal, using protein surgery is addressed.

TL;DR: Three important guidelines for the successful development of a particulate formulation of long pulmonary duration of action are revealed and Liposomes and other inhaled particulate systems formulated with these guidelines in mind may play an important pulmonary drug-delivery role for many therapeutic molecules, including those targeted for systemic absorption.

TL;DR: There are a number of issues unique to the pharmacokinetic evaluation of protein therapeutic agents, and currently there are many unanswered questions in need of good basic research to allow reasonable, scientifically valid approaches to be developed.

TL;DR: This chapter reviews the current status, including major accomplishments, technical problems and some proposed strategies, of the targeting of tumors with radiolabeled antibodies for imaging and treatment and the ability of a radioantibody to localize in a tumor.

TL;DR: Reviews on those recent developments in basic Biomedical Sciences which are likely to influence directly and significantly the research on drug delivery to, and through, the respiratory tract are published.

TL;DR: A wide range of agonists and antagonists of mucus secretion have been identified as have a number of substances which interact and affect its clearance.

TL;DR: In this paper, the authors present current aspects of transvascular exchange for solutes and water in the microcirculation and discuss various concepts concerning the modulation of the barrier in inflammatory-like states.

TL;DR: An important role for the airway circulation in the delivery or absorption of pharmacologic agents within the conducting airways is implied.

TL;DR: An overview of the unanswered problems is given, within a broad framework pointing to directions that may be expected to clarify the complexities of the bronchopulmonary immune response.

TL;DR: Aerosolized pentamidine has been studied with respect to the above factors, and has been shown to be clearly efficacious in the prevention of Pneumocystis carinii pneumonia, and should serve as a model for the testing of topical antibiotic therapy in other conditions.

TL;DR: Microspherical systems suitable for embolisation (diameter greater than 10 μm) offer most efficient localisation and retention in the lung vasculature: subsequent events relevant to relocation of active agents incorporated in microspheres from vasculatures to tumour tissue are also considered.

TL;DR: The nature of receptor dysfunction in airways disease must be established to determine whether agonists or antagonists are necessary to restore this dysfunction towards normality.