Andreas S. Tolias

TL;DR: This comprehensive profiling of neuronal cell types and connections in adult neocortex provides the most complete wiring diagram of neocortical microcircuits to date and should aid efforts to identify specific circuit abnormalities in animal models of brain disease and may eventually provide a path toward the development of comprehensive circuit-based, cell type–specific interventions.

TL;DR: The findings suggest a refinement of current models of cortical microcircuit architecture and function: Either adjacent neurons share only a few percent of their inputs or, alternatively, their activity is actively decorrelated.

TL;DR: By taking fluctuations in state into account, neural response (co)variability is significantly reduced, revealing the brain to be more reliable and predictable than previously thought.

TL;DR: It is demonstrated that rapid variations in cortical state during wakefulness are highly correlated with fluctuations in the activity of corticopetal noradrenergic and cholinergic projections.

TL;DR: A set of tools to solve the problem of decoding the spike times of the recorded neurons from the raw data captured from the probes, implemented in a suite of practical, user-friendly, open-source software is presented.