O. Berk Usta

TL;DR: A new technique based on subzero nonfreezing preservation and extracorporeal machine perfusion is presented that allows transplantation of rat livers preserved for up to four days, thereby tripling the viable preservation duration.

TL;DR: It is shown that hydrodynamic interactions in large polymers can be systematically coarse-grained to substantially reduce the computational cost of the simulation, and the results support the qualitative conclusions of recent Brownian dynamics simulations of confined polymers.

TL;DR: The modified PDMS was biocompatible, displaying no adverse effects when used in a simple liver-on-a-chip model using primary rat hepatocytes, and can be further applied in analytical separations, biosensing, cell studies, and drug-related studies.

TL;DR: Recent advances in surface molecular treatments to prevent fouling of PDMS surfaces are focused on towards improving its utility and expanding its use cases in biomedical applications.

TL;DR: This review of recent advances mainly since 2010 will first introduce general characteristics of droplet-based microfluidic devices for cell encapsulation with an emphasis on the fluid dynamics of droplets breakup and internal mixing as they directly influence microcapsule's size and structure, and discuss two on-chip manipulation strategies.