Young Bok Abraham Kang

TL;DR: It is believed that this liver model closely mimics the in vivo liver sinusoid and supports long‐term primary liver cell culture and could be extended to diverse liver biology studies and liver‐related disease research such as drug induced liver toxicology, cancer research, and analysis of pathological effects and replication strategies of various hepatotropic infectious agents.

TL;DR: The modified PDMS was biocompatible, displaying no adverse effects when used in a simple liver-on-a-chip model using primary rat hepatocytes, and can be further applied in analytical separations, biosensing, cell studies, and drug-related studies.

TL;DR: The Metabolic Patterning on a Chip (MPOC) platform capable of dynamically creating metabolic patterns across the length of a microchamber of liver tissue via actively enforced gradients of various metabolic modulators such as hormones and inducers is introduced.

TL;DR: It is demonstrated that primary hepatocytes can be cultured for extended times and retain their hepatocyte-specific functions when layered with endothelial cells.

TL;DR: The ability to detect HBV replication and Hepatitis B core Antigen (HBcAg) expression in the microfluidic platform confirmed that hepatocyte differentiation and functions were retained throughout the time course of the authors' studies.