O
Ofer Binah
Researcher at Technion – Israel Institute of Technology
Publications - 144
Citations - 5921
Ofer Binah is an academic researcher from Technion – Israel Institute of Technology. The author has contributed to research in topics: Induced pluripotent stem cell & Myocyte. The author has an hindex of 36, co-authored 138 publications receiving 5557 citations. Previous affiliations of Ofer Binah include Columbia University & Medical Corps.
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Journal ArticleDOI
Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes.
Izhak Kehat,Dorit Kenyagin-Karsenti,Mirit Snir,Hana Segev,Michal Amit,Amira Gepstein,Erella Livne,Ofer Binah,Joseph Itskovitz-Eldor,Lior Gepstein +9 more
TL;DR: The human ES cell--derived cardiomyocytes displayed structural and functional properties of early-stage cardiomers, which may have significant impact on the study of early human cardiac differentiation, functional genomics, pharmacological testing, cell therapy, and tissue engineering.
Journal ArticleDOI
Genetically Determined Heterogeneity in Hemoglobin Scavenging and Susceptibility to Diabetic Cardiovascular Disease
Rabea Asleh,Stuart Marsh,Mark Shilkrut,Ofer Binah,Julia Guetta,Flavio Lejbkowicz,Ben Enav,Naim Shehadeh,Yoram Kanter,Orit Lache,Osher Cohen,Nina S. Levy,Andrew P. Levy +12 more
TL;DR: It is proposed that the specific interaction between diabetes, CVD, and Hp genotype is the result of the heightened urgency of rapidly clearing glycosylated Hp‐Hp complexes from the subendothelial space before they can oxidatively modify low‐ density lipoprotein to atherogenic oxidized low‐density lipop protein.
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Functional properties of human embryonic stem cell-derived cardiomyocytes: intracellular Ca2+ handling and the role of sarcoplasmic reticulum in the contraction.
Katya Dolnikov,Mark Shilkrut,Naama Zeevi-Levin,Sharon Gerecht-Nir,Michal Amit,Asaf Danon,Joseph Itskovitz-Eldor,Ofer Binah +7 more
TL;DR: It is shown for the first time that functional properties related to intracellular Ca2+ handling of hESC‐CMs differ markedly from the adult myocardium, probably due to immature sarcoplasmic reticulum capacity.
Journal ArticleDOI
Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation
Atara Novak,Lili Barad,Naama Zeevi-Levin,Revital Shick,Ronit Shtrichman,Avraham Lorber,Avraham Lorber,Joseph Itskovitz-Eldor,Joseph Itskovitz-Eldor,Ofer Binah +9 more
TL;DR: The results demonstrate that the patient‐specific mutated cardiomyocytes can be used to study the electrophysiological mechanisms underlying CPVT, and investigate catecholamine‐induced arrhythmias in the CASQ2 mutated cells.
Journal ArticleDOI
Molecular characterization and functional properties of cardiomyocytes derived from human inducible pluripotent stem cells
Igal Germanguz,Oshra Sedan,Oshra Sedan,Naama Zeevi-Levin,Naama Zeevi-Levin,Ronit Shtrichman,Ronit Shtrichman,Efrat Barak,Efrat Barak,Anna Ziskind,Anna Ziskind,Sivan Eliyahu,Sivan Eliyahu,Gideon Meiry,Gideon Meiry,Michal Amit,Michal Amit,Joseph Itskovitz-Eldor,Joseph Itskovitz-Eldor,Ofer Binah,Ofer Binah +20 more
TL;DR: This study demonstrates that in the cardiomyocytes clones differentiated from HFF‐derived iPS, the functional properties related to excitation–contraction coupling, resemble in part those of adult card iomyocytes.