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Flavio Lejbkowicz

Researcher at Technion – Israel Institute of Technology

Publications -  84
Citations -  6721

Flavio Lejbkowicz is an academic researcher from Technion – Israel Institute of Technology. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 33, co-authored 77 publications receiving 5284 citations. Previous affiliations of Flavio Lejbkowicz include Rappaport Faculty of Medicine & Dartmouth College.

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Association analysis identifies 65 new breast cancer risk loci

Kyriaki Michailidou, +396 more
- 02 Nov 2017 - 
TL;DR: A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average.
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Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

Nasim Mavaddat, +310 more
- 03 Jan 2019 - 
TL;DR: This PRS, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset is developed and empirically validated and is a powerful and reliable predictor of breast cancer risk that may improve breast cancer prevention programs.
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Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk

Fergus J. Couch, +261 more
- 27 Mar 2013 - 
TL;DR: It is estimated that the breast cancer lifetime risks for the5% of BRCA1 carriers at lowest risk are 28%–50% compared to 81%–100% for the 5% at highest risk, and the ovarian cancer lifetime risk is 63% or higher, based on the known cancer risk-modifying loci.
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Discovery of common and rare genetic risk variants for colorectal cancer

Jeroen R. Huyghe, +224 more
- 01 Jan 2019 - 
TL;DR: Genome-wide association analyses based on whole-genome sequencing and imputation identify 40 new risk variants for colorectal cancer, including a strongly protective low-frequency variant at CHD1 and loci implicating signaling and immune function in disease etiology.
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Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers

Antonis Antoniou, +137 more
- 11 Apr 2008 - 
TL;DR: Differences in the effects of the FGFR2 and MAP3K1 SNPs between BRCA1 and BRCa2 carriers point to differences in the biology of BRC a1 and bRCA2 breast cancer tumors and confirm the distinct nature of breast cancer in BRC A1 mutation carriers.