Oleksiy Tsybrovskyy

TL;DR: It is demonstrated that DDC feeding in mice leads to a reactive phenotype of cholangiocytes and bile duct injury, pericholangitis, periductal fibrosis, ductular reaction, and consequently portal-portal bridging, and down-regulation of Mrp2 and impaired glutathione excretion, which may be valuable to investigate the mechanisms of xenobiotic-induced chronicCholangiopathies and its sequels including biliary fibrosis.

TL;DR: 24-norUrsodeoxycholic acid markedly improved liver tests and liver histology and significantly reduced hydroxyproline content and the number of infiltrating neutrophils and proliferating hepatocytes and cholangiocytes in Mdr2(-/-) mice.

TL;DR: UDCA aggravates bile infarcts and hepatocyte necroses in mice with biliary obstruction via disruption of cholangioles as a result of increased biliary pressure caused by its choleretic action.

TL;DR: Overexpression of Mrp 3 and Mrp 4 in CBDL mice is FXR independent and could play an important role in the adaptive hepatic ABC transporter response to cholestasis, which suggests that development of bile infarcts is related to bile acid-dependent bile flow and biliary pressure.

TL;DR: The data suggest that FXR loss significantly reduces fibrosis of the biliary type, but has no impact on non-cholestatic liver fibrosis.