O
Olga Kifor
Researcher at Brigham and Women's Hospital
Publications - 68
Citations - 11596
Olga Kifor is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Calcium-sensing receptor & Parathyroid chief cell. The author has an hindex of 51, co-authored 68 publications receiving 11241 citations. Previous affiliations of Olga Kifor include Harvard University & University of Picardie Jules Verne.
Papers
More filters
Journal ArticleDOI
Sodium and Ionic Strength Sensing by the Calcium Receptor
TL;DR: Parathyroid cells were potently modulated by ionic strength, with addition of 40 mm NaCl shifting the EC50 for [Ca2+] o inhibition of parathyroid hormone by at least 0.5 mm, and ions had an inverse effect on the sensitivity of CaR to its agonists.
Journal ArticleDOI
Identification and localization of the extracellular calcium-sensing receptor in human breast
Ivan Cheng,Mary E. Klingensmith,Naibedya Chattopadhyay,Olga Kifor,Robert Butters,David I. Soybel,Edward M. Brown +6 more
TL;DR: Findings indicate the presence of CaR mRNA and protein in the breast, providing indirect evidence that the CaR may have some role(s) in the control of Ca2+ transport, epithelial cell proliferation, and/or other processes in normal and abnormal breast tissue.
Journal ArticleDOI
A Syndrome of Hypocalciuric Hypercalcemia Caused by Autoantibodies Directed at the Calcium-Sensing Receptor
Olga Kifor,Francis D. Moore,Miriam Delaney,Jeffrey R. Garber,Jeffrey R. Garber,Geoffrey N. Hendy,Robert Butters,Ping Gao,Thomas Cantor,Imre Kifor,Edward M. Brown,John J. Wysolmerski +11 more
TL;DR: A biochemical phenotype of PTH-dependent hypercalcemia resembling that caused by heterozygous inactivating mutations of the CaR in familial hypocalciuric hypercalcesmia can be observed in patients with antibodies to theCaR's extracellular domain that stimulate PTH release.
Journal ArticleDOI
The calcium-sensing receptor is localized in caveolin-rich plasma membrane domains of bovine parathyroid cells.
TL;DR: It is demonstrated that the recently characterized Ca2+ o -sensing receptor (CaR) resides within caveolin-rich membrane domains in bovine parathyroid cells, suggesting that CaR-mediated signal transduction potentially involved in Ca2 + o -regulated processes in parathyoid cells occur in caveolae-like domains.
Journal ArticleDOI
Activating antibodies to the calcium-sensing receptor in two patients with autoimmune hypoparathyroidism.
Olga Kifor,Aidan McElduff,Meryl S. LeBoff,Francis D. Moore,Robert Butters,Ping Gao,Thomas Cantor,Imre Kifor,Edward M. Brown +8 more
TL;DR: It is demonstrated that patients with the biochemical findings of primary hypoparathyroidism can harbor activating antibodies to the CaR, which, in the two cases studied here, did not produce irreversible destruction of the parathyroid glands.