O
Olga Kifor
Researcher at Brigham and Women's Hospital
Publications - 68
Citations - 11596
Olga Kifor is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Calcium-sensing receptor & Parathyroid chief cell. The author has an hindex of 51, co-authored 68 publications receiving 11241 citations. Previous affiliations of Olga Kifor include Harvard University & University of Picardie Jules Verne.
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Journal ArticleDOI
Expression of Extracellular Calcium-Sensing Receptor by Human Lens Epithelial Cells
Naibedya Chattopadhyay,Chianping Ye,Dhirendra P. Singh,Olga Kifor,Peter M. Vassilev,Toshimiki Shinohara,Leo T. Chylack,Edward M. Brown +7 more
TL;DR: The data suggest that human lens-epithelial cells express the CaR, which may be functionally linked to Ca(2+)-activated K+ channels and, perhaps, to other ion channels involved in ionic homeostasis in the lens.
Journal ArticleDOI
Extracellular calcium (Ca2+o)-sensing receptor in a mouse monocyte-macrophage cell line (J774) : Potential mediator of the actions of Ca2+o on the function of J774 cells
TL;DR: The data strongly suggest that the monocyte‐macrophage cell line, J774, possesses both CaR protein and mRNA very similar, if not identical, to those in parathyroid and kidney.
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m-Calpain colocalizes with the calcium-sensing receptor (CaR) in caveolae in parathyroid cells and participates in degradation of the CaR.
TL;DR: The data suggest that localization of m-Calpain within caveolae may contribute to maintenance of the enzyme in an inactive state and that m-calpain may also contribute to the regulation of CaR levels.
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Asymmetrical, agonist-induced fluctuations in local extracellular [Ca2+] in intact polarized epithelia
Rosa Caroppo,Andrea Gerbino,Lucantonio Debellis,Olga Kifor,David I. Soybel,David I. Soybel,Edward M. Brown,Aldebaran M. Hofer,Aldebaran M. Hofer,Silvana Curci +9 more
TL;DR: The data indicate that agonist stimulation results in local fluctuations in [Ca2+]ext that would be sufficient to modulate the activity of the CaR on neighboring cells.
Journal ArticleDOI
Protein kinase C (PKC) phosphorylation of the Ca2+ o-sensing receptor (CaR) modulates functional interaction of G proteins with the CaR cytoplasmic tail.
TL;DR: Interestingly, truncating the receptor at 888 had an even more pronounced negative effect on CaR-elicited release of intracellular Ca2+ stores without significantly affectingCaR-mediated activation of Ca2+, suggesting that PKC phosphorylation of the CaR prevents G protein subtypes from interacting with the region of the receptor critical for releasing Ca2+.