Olga Kifor

TL;DR: In this article, the effects of the mutations on extracellular calcium and gadolinium-elicited increases in the cytosolic calcium concentration were examined and the mechanisms by which the mutations alter the function of the receptor may help to discern the structure-function relationships in terms of ligand-binding and G protein coupling.

TL;DR: C cells express the same extracellular calcium-sensing receptor that is found in parathyroid and kidney, and the presence of this receptor protein in C cell lines correlates with the extrace Cellular calcium-Sensing function.

TL;DR: The data suggest that the CaR activates MAPK through PKC, presumably through Gq/11-mediated activation of PI-PLC, as well as through G(i)- and PTK-dependent pathway(s) in bovine parathyroid and HEKCaR cells and indicate the importance of MAPK in cPLA2 activation.

TL;DR: The data strongly suggest that the osteoblastic cell line MC3T3‐E1 possesses both CaR protein and mRNA very similar, if not identical, to those in parathyroid and kidney, and the CaR in these osteoblasts could play a key role in regulating bone turnover by stimulating the proliferation and migration of such cells to sites of bone resorption as a result of local release of Ca2+o.

TL;DR: Data suggest that polyamines could be effective agonists for the CaR, and several tissues, including the brain, may use theCaR as a target for the actions of spermine and other endogenous polycationic agonists.