O
Olga Tsigkou
Researcher at University of Manchester
Publications - 28
Citations - 2213
Olga Tsigkou is an academic researcher from University of Manchester. The author has contributed to research in topics: Bioactive glass & Bone regeneration. The author has an hindex of 19, co-authored 26 publications receiving 1933 citations. Previous affiliations of Olga Tsigkou include Harvard University & Academy of Athens.
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Journal ArticleDOI
Extracellular matrix formation and mineralization on a phosphate-free porous bioactive glass scaffold using primary human osteoblast (HOB) cells.
TL;DR: The scaffolds supported osteoblast growth and induced differentiation, within the 3-week culture period, as depicted by enhanced ALPase enzymatic activity, without the addition of supplementary factors such as ascorbic acid, beta-glycerophosphate and dexamethasone.
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Differentiation of fetal osteoblasts and formation of mineralized bone nodules by 45S5 Bioglass conditioned medium in the absence of osteogenic supplements.
TL;DR: Treatment with B GCM/15 and BGCM/20 in the absence of osteogenic supplements increased the gene expression of the bone extracellular matrix proteins alkaline phosphatase, osteonectin and bone sialoprotein as determined by quantitative real time reverse transcriptase-polymerase chain reaction (rt RT-PCR) analysis.
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Engineered vascularized bone grafts
Olga Tsigkou,Irina Pomerantseva,Joel A. Spencer,Joel A. Spencer,Patricia A. Redondo,Alison Hart,Elisabeth M. O’Doherty,Yunfeng Lin,Claudia C. Friedrich,Laurence Daheron,Charles P. Lin,Cathryn A. Sundback,Joseph P. Vacanti,Craig M. Neville +13 more
TL;DR: Clinical relevant progenitor sources for pericytes and endothelial cells can serve to generate highly functional microvascular networks for tissue engineered bone grafts.
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Silica-gelatin hybrids with tailorable degradation and mechanical properties for tissue regeneration
Oliver Mahony,Olga Tsigkou,Claudia Ionescu,Caterina Minelli,Lowell Ling,Ruth Hanly,Mark E. Smith,Molly M. Stevens,Julian R. Jones +8 more
TL;DR: These novel materials, based on a silica‐gelatin hybrid system, have the potential to serve as a platform technology for human tissue regeneration and demonstrate a non‐cytotoxic effect when mesenchymal stem cells are cultured on the material.
Journal ArticleDOI
Spherical bioactive glass particles and their interaction with human mesenchymal stem cells in vitro
Sheyda Labbaf,Olga Tsigkou,Karin H. Müller,Karin H. Müller,Molly M. Stevens,Alexandra E. Porter,Julian R. Jones +6 more
TL;DR: Findings are important for assessing the toxicity of sub-micron particles that may either be used as injectables for bone regeneration or generated by wear or degradation of bioactive glass scaffolds.