Deborah J. Good

TL;DR: A secreted inhibitor of angiogenesis that is controlled by a tumor suppressor gene in hamster cells has been found to be similar to a fragment of the platelet and matrix protein thrombospondin, which demonstrates a function for the ubiquitous adhesive glycoprotein thromBosponin that is likely to be important in the normal physiological down-regulation of neovascularization.

TL;DR: The results suggest that the large TSP1 molecule employs at least two different structural domains and perhaps two different mechanisms to accomplish a single physiological function, the inhibition of neovascularization.

TL;DR: It is shown that mouse embryos lacking the early-response gene SIL have axial midline defects, a block in midline Sonic hedgehog (Shh) signalling and randomized cardiac looping, and that the consequences of abnormal midline development for left–right patterning depend on the time of onset, duration and severity of disruption of the normal asymmetric patterns of expression of nodal, lefty-2 and Pitx2.

TL;DR: A role for Nhlh2 in the onset of puberty and the regulation of body weight metabolism is supported, as well as a disruption of the hypothalamic-pituitary axis in mice.

TL;DR: It is shown that Nhlh2 is expressed throughout the adult hypothalamus, and a direct role for transcriptional control of neuropeptide processing enzymes in the etiology of adult-onset obesity is supported.