Oliver Frings

TL;DR: A two-pass BLAST approach was developed that makes use of high-precision compositional score matrix adjustment, but avoids the alignment truncation that sometimes follows in homology assignment.

TL;DR: It is demonstrated that Kalign2 is exceptionally fast and memory-efficient, permitting accurate alignment of very large numbers of sequences, and the potential of using known or predicted sequence annotation to improve the alignment accuracy is demonstrated.

TL;DR: This work develops a robust mass spectrometry-based analysis pipeline to generate a proteome-wide view of subcellular localization for proteins mapping to 12,418 individual genes across five cell lines, and investigates the effect of alternative splicing and protein domains on localization, complex member co-localization, cell-type-specific localization, as well as protein relocalization after growth factor inhibition.

TL;DR: Key components of a signaling network that maintains the protumoral functions of CXCL14-stimulated CAF are defined, and NOS1 is identified as intervention target for CAF-directed cancer therapy.

TL;DR: It is suggested that diminished downstream Hh signalling enhances CRC development, and that stromal Hh activation can act as a colonic tumour suppressor.