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Simon Joost
Researcher at Karolinska Institutet
Publications - 14
Citations - 2028
Simon Joost is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Hair follicle & Stem cell. The author has an hindex of 9, co-authored 11 publications receiving 1514 citations. Previous affiliations of Simon Joost include University of Marburg.
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Journal ArticleDOI
Quantitative single-cell RNA-seq with unique molecular identifiers
Saiful Islam,Amit Zeisel,Simon Joost,Gioele La Manno,Pawel Zajac,Maria Kasper,Peter Lönnerberg,Sten Linnarsson +7 more
TL;DR: It is shown that molecular labels—random sequences that label individual molecules—can nearly eliminate amplification noise, and that microfluidic sample preparation and optimized reagents produce a fivefold improvement in mRNA capture efficiency.
Journal ArticleDOI
Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity
Simon Joost,Amit Zeisel,Tina Jacob,Xiaoyan Sun,Gioele La Manno,Peter Lönnerberg,Sten Linnarsson,Maria Kasper +7 more
TL;DR: An unbiased and systematic view of transcriptional organization of adult epidermis is provided and how cellular heterogeneity can be orchestrated in vivo to assure tissue homeostasis is highlighted.
Journal ArticleDOI
The Molecular Anatomy of Mouse Skin during Hair Growth and Rest.
Simon Joost,Karl Annusver,Tina Jacob,Xiaoyan Sun,Tim Dalessandri,Unnikrishnan Sivan,Inês Sequeira,Rickard Sandberg,Maria Kasper +8 more
TL;DR: This work uses single-cell RNA sequencing and single-molecule RNA FISH to provide a systematic molecular atlas of full-thickness skin, determining gene expression profiles and spatial locations that define 56 cell types and states during hair growth and rest.
Journal ArticleDOI
Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing
Simon Joost,Tina Jacob,Xiaoyan Sun,Karl Annusver,Gioele La Manno,Inderpreet Sur,Maria Kasper +6 more
TL;DR: How different SCs respond and adapt to a new environment is revealed, potentially explaining cellular plasticity of many epithelial tissues.
Journal ArticleDOI
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
Marco Gerling,Nikè V. J. A. Büller,Leonard M. Kirn,Leonard M. Kirn,Simon Joost,Oliver Frings,Benjamin Englert,Benjamin Englert,Åsa Bergström,Raoul Kuiper,Leander Blaas,Mattheus C. B. Wielenga,Sven Almer,Sven Almer,Anja A. Kühl,Erik Fredlund,Gijs R. van den Brink,Rune Toftgård +17 more
TL;DR: It is suggested that diminished downstream Hh signalling enhances CRC development, and that stromal Hh activation can act as a colonic tumour suppressor.