Oliver Pabst

TL;DR: A model of stepwise oral tolerance induction induction comprising the generation of Treg cells in the gut-draining lymph nodes, followed by migration into the gut and subsequent expansion of T Reg cells driven by intestinal macrophages is proposed.

TL;DR: Results demonstrate a unique function for LP-derived CD103+ MLN DCs in the generation of gut-tropic effector T cells in vitro.

TL;DR: Findings indicate that selectively CD103+ DCs serve classical DC functions and initiate adaptive immune responses in local LNs, whereas CX3CR1+ populations might modulate immune responses directly in the mucosa and serve as first line barrier against invading enteropathogens.

TL;DR: It is demonstrated that antigen transport via afferent lymphatics into the draining mesenteric lymph nodes is obligatory for oralolerance induction, inspiring new therapeutic strategies to exploit oral tolerance induction for the prevention and treatment of autoimmune diseases.

TL;DR: Small intestinal CD103+ DCs represent a potential novel target for regulating human intestinal inflammatory responses and are shown to represent a tissue-derived migratory population that plays a central role in presenting orally derived soluble antigen to CD8+ and CD4+ T cells.