O
Oliver Rath
Researcher at University of Glasgow
Publications - 26
Citations - 4316
Oliver Rath is an academic researcher from University of Glasgow. The author has contributed to research in topics: MAPK/ERK pathway & Signal transduction. The author has an hindex of 20, co-authored 25 publications receiving 3811 citations. Previous affiliations of Oliver Rath include London Research Institute & Boehringer Ingelheim.
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Journal ArticleDOI
MAP kinase signalling pathways in cancer.
TL;DR: Recent findings and hypotheses on the role of MAPK pathways in cancer are discussed, with a focus on stress-activated pathways, which largely seem to counteract malignant transformation.
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Kinesins and cancer
Oliver Rath,Frank Kozielski +1 more
TL;DR: Three compounds that inhibit two mitotic kinesins (EG5 (also known as KIF11) and centromere-associated protein E (CENPE) have entered clinical trials either as monotherapies or in combination with other drugs.
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Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway.
Sung-Young Shin,Oliver Rath,Sang Mok Choo,Frances Fee,Brian McFerran,Brian McFerran,Walter Kolch,Kwang-Hyun Cho +7 more
TL;DR: It is shown that the negative-feedback loop from ERK to SOS plays a crucial role in generating an oscillatory behavior of ERK activity, and positive- and negative-Feedback loops and RKIP work together to shape the response pattern and dynamical characteristics of the ERK pathway.
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A hidden oncogenic positive feedback loop caused by crosstalk between Wnt and ERK Pathways
TL;DR: This study adds a novel aspect to the molecular mechanisms of carcinogenesis by showing that mutational changes in individual proteins can cause fundamental functional changes well beyond the pathway they function in by a positive feedback loop embedded in crosstalk.
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Functional roles of multiple feedback loops in extracellular signal-regulated kinase and Wnt signaling pathways that regulate epithelial-mesenchymal transition.
Sung-Young Shin,Oliver Rath,Armin Zebisch,Armin Zebisch,Sang Mok Choo,Walter Kolch,Kwang-Hyun Cho +6 more
TL;DR: The results show that the feedbacks can generate a rich dynamic behavior leading to various dose-response patterns and have a decisive role in determining network responses to EGF and Wnt, and provide a system-level understanding of how RKIP can regulate EMT progression and may explain why RK IP is downregulated in so many metastatic cancer cells.