O
Oliver Smithies
Researcher at University of Wisconsin-Madison
Publications - 71
Citations - 25049
Oliver Smithies is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Gene & Globin. The author has an hindex of 41, co-authored 71 publications receiving 24915 citations. Previous affiliations of Oliver Smithies include University of Toronto & Wayne State University.
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Journal ArticleDOI
A comprehensive set of sequence analysis programs for the VAX
TL;DR: A group of programs that will interact with each other has been developed for the Digital Equipment Corporation VAX computer using the VMS operating system.
Journal ArticleDOI
The structure and evolution of the human β-globin gene family
Argiris Efstratiadis,James W. Posakony,Tom Maniatis,Richard M. Lawn,Catherine O'Connell,Richard A. Spritz,Jon K. deRiel,Bernard G. Forget,Sherman M. Weissman,Jerry L. Slightom,Ann E. Blechl,Oliver Smithies,Francisco E. Baralle,Carol C. Shoulders,Nick J. Proudfoot +14 more
TL;DR: A model for the involvement of short direct repeat sequences in the generation of deletions in the noncoding and coding regions of B-like globin genes during evolution is described.
Journal ArticleDOI
Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination.
TL;DR: A ‘rescuable’ plasmid containing globin gene sequences allowing recombination with homologous chromosomal sequences has enabled us to produce, score and clone mammalian cells with the plasmids integrated into the human β-globin locus.
The Structure and Evolution of the Human /?-Globin Gene Family
Argiris Efstratiadis,James W. Posakony,Tom Maniatis,Richard M. Lawn,Richard A. Spritz,Jon K. deRiel,Forget Bg,Sherman M. Weissman,Jerry L. Slightom,Ann E. Blechl,Oliver Smithies,F.E. Baralle,Carol C. Shoulders,Nicholas J. ProudfootQ +13 more
TL;DR: Efstratiadis et al. as mentioned in this paper presented the results of a detailed comparison of the primary structure of human p-like globin genes and their flanking sequences.
Journal ArticleDOI
Human fetal gγ- and Aγ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes
TL;DR: The sequence data suggest that intergenic conversions occur in the germ line, and strongly suggest that DNA sequence polymorphisms for localized deletions, additions and base substitutions are very common in human populations.