O
Oliver Smithies
Researcher at University of Wisconsin-Madison
Publications - 71
Citations - 25049
Oliver Smithies is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Gene & Globin. The author has an hindex of 41, co-authored 71 publications receiving 24915 citations. Previous affiliations of Oliver Smithies include University of Toronto & Wayne State University.
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Journal ArticleDOI
Cloning human fetal γ globin and mouse α-type globin DNA: Preparation and screening of shotgun collections
Frederick R. Blattner,Ann E. Blechl,Katherine Denniston-Thompson,Harvey E. Faber,Julia E. Richards,Jerry L. Slightom,Phillip W. Tucker,Oliver Smithies +7 more
TL;DR: Shotgun collections of Charon 3A bacteriophages containing Eco RI fragments of human and mouse DNA were constructed with the use of in vitro packaging using the Southern method of hybridization to detect globin-specific clones.
Journal ArticleDOI
Chromosomal rearrangements and the evolution of haptoglobin genes.
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Duplication within the haptoglobin Hp2 gene.
TL;DR: DNA sequencing shows that the intragenic duplication within the human haptoglobin Hp2 allele was formed by a non-homologous, probably random, crossing-over within different introns of two Hp1genes, probably in an Hp 1F/Hp1S heterozygote.
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Initiation of protein synthesis at an unusual position in an immunoglobulin gene
Oliver Smithies,M. D. Poulik +1 more
TL;DR: The amino acid sequence of urinary β2-microglobulin has been partially determined and found to be related to the constant region of IgG immunoglobulin heavy chain.
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Unexpected relationships between four large deletions in the human β-globin gene cluster
TL;DR: It is shown, by comparing DNA sequences, that the deletions are due to non-homologous DNA exchanges, and the results suggest that the four deletions were generated by a common mechanism.