O
Olof Sydow
Researcher at Karolinska University Hospital
Publications - 56
Citations - 2681
Olof Sydow is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Parkinson's disease & Single-nucleotide polymorphism. The author has an hindex of 28, co-authored 56 publications receiving 2495 citations. Previous affiliations of Olof Sydow include University of Colorado Denver & Karolinska Institutet.
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Journal ArticleDOI
Long-term efficacy of thalamic deep brain stimulation for tremor: double-blind assessments.
TL;DR: It is concluded that high‐frequency electric thalamic stimulation can efficiently suppress severe tremor in PD and ET more than 6 years after permanent implantation of brain electrodes.
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Multicentre European study of thalamic stimulation in essential tremor: a six year follow up.
TL;DR: Good reduction in tremor can be maintained for more than six years in the majority of severely disabled patients, and thalamic stimulation can be recommended in essential tremor where there is insufficient response to drug treatment.
Journal ArticleDOI
LRRK2 expression linked to dopamine-innervated areas.
TL;DR: This study explores the expression of LRRK2 in human and rodent brain tissue and finds that high levels of expression are associated with Parkinson's disease.
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NURR1 mutations in cases of schizophrenia and manic-depressive disorder.
Silvia Buervenich,Andrea Carmine,Mariette Arvidsson,Fengqing Xiang,Zhiping Zhang,Olof Sydow,Erik G. Jönsson,Göran Sedvall,S. Leonard,Randal G. Ross,Robert Freedman,Kodavali V. Chowdari,Vishwajit L. Nimgaonkar,Thomas Perlmann,Maria Anvret,Lars Olson +15 more
TL;DR: There is a highly homologous NURR1 gene in humans which therefore constitutes a good candidate gene for neurologic and psychiatric disorders with an involvement of the dopamine neuron system, such as Parkinson's disease, schizophrenia, and manic-depression.
Journal ArticleDOI
Multicentre European study of thalamic stimulation for parkinsonian tremor: a 6 year follow-up
Marwan Hariz,Paul Krack,François Alesch,L-E Augustinsson,A. Bosch,R. Ekberg,F Johansson,Bo Johnels,Björn A. Meyerson,J-P N'Guyen,M M Pinter,Pierre Pollak,F. von Raison,Stig Rehncrona,Johannes D. Speelman,Olof Sydow,A. L. Benabid +16 more
TL;DR: Vim DBS, although having no effect on akinesia and rigidity, is a relatively lenient surgical procedure and may still have a place for long term symptomatic control of PD tremor in selected patients.