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Shinichiro Motohashi
Researcher at Chiba University
Publications - 112
Citations - 5200
Shinichiro Motohashi is an academic researcher from Chiba University. The author has contributed to research in topics: Natural killer T cell & Immunotherapy. The author has an hindex of 34, co-authored 103 publications receiving 4570 citations.
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Journal ArticleDOI
A Phase I Study of α-Galactosylceramide (KRN7000)–Pulsed Dendritic Cells in Patients with Advanced and Recurrent Non–Small Cell Lung Cancer
Aki Ishikawa,Shinichiro Motohashi,Eiichi Ishikawa,Hiroki Fuchida,Kazuko Higashino,Mizuto Otsuji,Toshihiko Iizasa,Toshinori Nakayama,Masaru Taniguchi,Takehiko Fujisawa +9 more
TL;DR: In this clinical trial, αGalCer-pulsed DC administration was well tolerated and could be safely done even in patients with advanced disease, and significant responses were seen in two cases receiving the level 3 dose.
Journal Article
Antitumor Cytotoxicity Mediated by Ligand-activated Human Vα24 NKT Cells
Tetsu Kawano,Toshinori Nakayama,Noriaki Kamada,Yoshikatsu Kaneko,Michishige Harada,Nobutaka Ogura,Yasunori Akutsu,Shinichiro Motohashi,Toshihiko Iizasa,Hideharu Endo,Takehiko Fujisawa,Hiroshi Shinkai,Masaru Taniguchi +12 more
TL;DR: It is demonstrated that the α-GalCer-activated Vα24 NKT cells exert a potent perforin-dependent cytotoxic activity against a wide variety of human tumor cell lines.
Journal ArticleDOI
Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells
Matthew J. Frigault,Jihyun Lee,Maria C. Basil,Carmine Carpenito,Shinichiro Motohashi,John Scholler,Omkar U. Kawalekar,Sonia Guedan,Shannon E. McGettigan,Avery D. Posey,Sonny Ang,Laurence J.N. Cooper,Jesse M. Platt,F. Brad Johnson,Chrystal M. Paulos,Yangbing Zhao,Michael Kalos,Michael C. Milone,Carl H. June +18 more
TL;DR: It is reported that certain CARs endow T cells with the ability to undergo long-term autonomous proliferation and the design of CARs that have a nonconstitutive growth phenotype may be a strategy to improve efficacy and engraftment of CAR T cells.
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The polycomb protein Ezh2 regulates differentiation and plasticity of CD4(+) T helper type 1 and type 2 cells.
Damon J. Tumes,Atsushi Onodera,Akane Suzuki,Kenta Shinoda,Yusuke Endo,Chiaki Iwamura,Hiroyuki Hosokawa,Haruhiko Koseki,Koji Tokoyoda,Yutaka Suzuki,Shinichiro Motohashi,Toshinori Nakayama +11 more
TL;DR: A functional link between Ezh2 and transcriptional regulation of lineage-specifying genes in terminally differentiated CD4(+) T cells is established and caused increased pathology in a model of allergic asthma and resulted in progressive accumulation of memory phenotype Th2 cells.
Journal ArticleDOI
A phase I study of in vitro expanded natural killer T cells in patients with advanced and recurrent non-small cell lung cancer
Shinichiro Motohashi,Aki Ishikawa,Eiichi Ishikawa,Mizuto Otsuji,Toshihiko Iizasa,Hideki Hanaoka,Naomi Shimizu,Shigetoshi Horiguchi,Yoshitaka Okamoto,Shin-ichiro Fujii,Masaru Taniguchi,Takehiko Fujisawa,Toshinori Nakayama +12 more
TL;DR: The clinical trial with activated Vα24 NKT cell administration was well tolerated and carried out safely with minor adverse events even in patients with advanced diseases.