O
Oommen P. Varghese
Researcher at Uppsala University
Publications - 59
Citations - 1866
Oommen P. Varghese is an academic researcher from Uppsala University. The author has contributed to research in topics: Self-healing hydrogels & Mesenchymal stem cell. The author has an hindex of 21, co-authored 53 publications receiving 1484 citations. Previous affiliations of Oommen P. Varghese include University of Tokyo & Science for Life Laboratory.
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Journal ArticleDOI
Bone reservoir: Injectable hyaluronic acid hydrogel for minimal invasive bone augmentation
Elena Martínez-Sanz,Dmitri A. Ossipov,Jöns Hilborn,Sune Larsson,Kenneth B. Jonsson,Oommen P. Varghese +5 more
TL;DR: The result suggests that novel HA hydrogels could be used as a BMP-2 carrier and can promote bone augmentation for potential orthopedic applications.
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In Situ Cross-Linkable High Molecular Weight Hyaluronan−Bisphosphonate Conjugate for Localized Delivery and Cell-Specific Targeting: A Hydrogel Linked Prodrug Approach
TL;DR: The first in vitro results showing that even though HA can target CD44 positive cancer cells, receptor mediated endocytosis could only occur by cleavage of high molecular weight HA with an ubiquitous enzyme, hyaluronidase (Hase) are presented.
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Smart Design of Stable Extracellular Matrix Mimetic Hydrogel: Synthesis, Characterization, and In Vitro and In Vivo Evaluation for Tissue Engineering
TL;DR: This novel crosslinking reaction is used to tailor a hyaluronan hydrogel, which delivered exceptional hydrolytic stability, mechanical properties, low swelling, and controlled enzymatic degradation.
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Bi-directional cell-pericellular matrix interactions direct stem cell fate
Silvia A. Ferreira,Meghna S. Motwani,Peter Faull,Alexis J. Seymour,Tracy T. L. Yu,Marjan Enayati,Marjan Enayati,Dheraj K. Taheem,Christoph Salzlechner,Tabasom Haghighi,Ewa M. Kania,Oommen P. Oommen,Tarek I Ahmed,Sandra Loaiza,Katarzyna Parzych,Francesco Dazzi,Oommen P. Varghese,Frederic Festy,Agamemnon E. Grigoriadis,Holger W. Auner,Ambrosius P. Snijders,Laurent Bozec,Laurent Bozec,Eileen Gentleman +23 more
TL;DR: It is shown that pericellular matrix secreted by human bone marrow stromal cells (hMSC) embedded in a HA-based hydrogel contribute to hMSC fate.
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Functionalization of Hyaluronic Acid with Chemoselective Groups via a Disulfide-Based Protection Strategy for In Situ Formation of Mechanically Stable Hydrogels
TL;DR: The new protective group strategy based on initial mild cleavage of a disulfide bond followed by elimination of the generated 2-thioethoxycarbonyl moiety ultimately affording free amine-type functionality, such as hydrazide, aminooxy, and carbazate is developed.