O
Osamu Hayaishi
Researcher at Kyoto University
Publications - 170
Citations - 10601
Osamu Hayaishi is an academic researcher from Kyoto University. The author has contributed to research in topics: Enzyme & Tryptophan. The author has an hindex of 56, co-authored 170 publications receiving 10456 citations. Previous affiliations of Osamu Hayaishi include Laboratory of Molecular Biology & Hokkaido University.
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Journal ArticleDOI
Poly(ADP-ribose) and ADP-ribosylation of proteins.
Osamu Hayaishi,K Ueda +1 more
TL;DR: This chapter analyzes poly(ADp-ribose) and ADP-ribosylation of proteins, a novel type of covalent modification of proteins that is implicated in the regulation of cell proliferation, protein synthesis, and DNA as well as RNA metabolism.
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Diphtheria Toxin-dependent Adenosine Diphosphate Ribosylation of Aminoacyl Transferase II and Inhibition of Protein Synthesis
TL;DR: In the presence of diphtheria toxin, the adenosine diphosphate ribose portion of nicotinamide adenine dinucleotide was transferred to aminoacyl transferase II obtained from rat liver, which resulted in a concurrent inactivation of this particular enzyme.
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Indoleamine 2,3-dioxygenase. Purification and some properties.
TL;DR: Indoleamine 2,3-dioxygenase was purified from rabbit small intestine to apparent homogeneity as judged by polyacrylamide gel electrophoresis and analytical ultracentrifugation.
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In Vitro and in Vivo Formation of Two New Metabolites of Melatonin
TL;DR: The results indicate that these two new metabolites are involved in the major metabolic pathway of melatonin in the central nervous system.
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Enzymic Studies on the Biosynthesis of Serotonin in Mammalian Brain
TL;DR: Tryptophan 5-monooxygenase activity is detected in both the soluble and particulate fractions from the guinea pig brain stem and the radioactive CO2 evolved is almost entirely accounted for by the formation of serotonin-14C.