O
Othmar Ludwiczek
Researcher at Harvard University
Publications - 25
Citations - 1955
Othmar Ludwiczek is an academic researcher from Harvard University. The author has contributed to research in topics: Inflammatory bowel disease & Ulcerative colitis. The author has an hindex of 13, co-authored 23 publications receiving 1772 citations. Previous affiliations of Othmar Ludwiczek include Innsbruck Medical University.
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Journal ArticleDOI
Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis
Arthur Kaser,Gerald Brandacher,W Steurer,Susanne Kaser,Susanne Kaser,Felix Offner,Heinz Zoller,Igor Theurl,Walter Widder,Clemens Molnar,Clemens Molnar,Othmar Ludwiczek,Othmar Ludwiczek,Michael B. Atkins,James W. Mier,Herbert Tilg +15 more
TL;DR: A novel pathway of TPO regulation by the inflammatory mediator IL-6 is proposed, indicating that the number of platelets by themselves might not be the sole determinant of circulating TPO levels and thus of thrombopoiesis.
Journal ArticleDOI
Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis.
Herbert Tilg,Rajiv Jalan,Arthur Kaser,Nathan Davies,Felix Offner,Stephen J. Hodges,Othmar Ludwiczek,Debbie L. Shawcross,Heinz Zoller,Akeel Alisa,Rajeshwar P. Mookerjee,Ivo Graziadei,Christian Datz,Michael Trauner,Detlef Schuppan,Peter Obrist,Wolfgang Vogel,Roger Williams +17 more
TL;DR: The data suggest that randomized controlled trials of anti-TNF antibody in severe AH are warranted, and there was an early, though not significant, decrease in plasma levels of proinflammatory cytokines, whereas Plasma levels of TNFalpha remained near the sensitivity limit of the assay throughout the treatment course.
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The RANKL/OPG system is activated in inflammatory bowel disease and relates to the state of bone loss
Alexander R. Moschen,Arthur Kaser,Barbara Enrich,Othmar Ludwiczek,M Gabriel,Peter Obrist,Anna Maria Wolf,Herbert Tilg +7 more
TL;DR: Applying results from a murine model of colitis associated bone loss, the constellation of OPG and sRANKL regulation observed in this study raises the possibility that RANKL/OPG may contribute to the development of bone loss in IBD.
Journal ArticleDOI
Increased Expression of CCL20 in Human Inflammatory Bowel Disease
Arthur Kaser,Othmar Ludwiczek,Sandra Holzmann,Alexander R. Moschen,Günter Weiss,Barbara Enrich,Ivo Graziadei,Stefan Dunzendorfer,Christian J. Wiedermann,Elisabeth Mürzl,Eveline Grasl,Zerina Jasarevic,Nikolaus Romani,Felix Offner,Herbert Tilg +14 more
TL;DR: CCL20 might regulate the attraction of T lymphocytes and dendritic cells in IBD, and abundant numbers of Langerin+ immature d endritic cells were identified in the subepithelial space of IBD specimens.
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Subfulminant hepatitis B after infliximab in Crohn’s disease: Need for HBV-screening?
TL;DR: A patient with Crohn's disease who developed subfulminant hepatitis B after the fourth infusion of infliximab due to an unrecognized HBs-antigen carrier state could have been prevented if screening for HBV and pre-emptive therapy with lamivudine would have been started prior to inflIXimab.