O
Ovijit Chaudhuri
Researcher at Stanford University
Publications - 80
Citations - 13181
Ovijit Chaudhuri is an academic researcher from Stanford University. The author has contributed to research in topics: Self-healing hydrogels & Extracellular matrix. The author has an hindex of 34, co-authored 70 publications receiving 9310 citations. Previous affiliations of Ovijit Chaudhuri include University of California, San Francisco & Lawrence Berkeley National Laboratory.
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Varying PEG density to control stress relaxation in alginate-PEG hydrogels for 3D cell culture studies.
TL;DR: Faster relaxation in RGD-coupled alginate-PEG hydrogels led to increased spreading and proliferation of fibroblasts, and enhanced osteogenic differentiation of mesenchymal stem cells (MSCs).
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Viscoplasticity Enables Mechanical Remodeling of Matrix by Cells.
TL;DR: This study rigorously characterized the plasticity in materials commonly used for cell culture and revealed time-dependent plasticity, or viscoplasticity, in collagen gels, reconstituted basement membrane matrix, agaroseGels, alginate Gels, and fibrin gles, but not in polyacrylamide gels.
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Beyond proteases: Basement membrane mechanics and cancer invasion
Julie Chang,Ovijit Chaudhuri +1 more
TL;DR: Chang and Chaudhuri discuss basement membrane mechanics and how cells use both proteolytic and physical mechanisms to invade basement membranes during cancer progression.
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Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility.
Ryan S. Stowers,Anna Shcherbina,Johnny Israeli,Joshua J. Gruber,Julie Chang,Sungmin Nam,Atefeh Rabiee,Mary N. Teruel,Michael Snyder,Anshul Kundaje,Ovijit Chaudhuri +10 more
TL;DR: 3D model of breast cancer shows that a stiff extracellular matrix promotes a tumorigenic phenotype through broad changes in chromatin accessibility and in the activity of histone deacetylases and the transcription factor Sp1, and reveals that chromatin state is a critical mediator of mechanotransduction.
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YAP-independent mechanotransduction drives breast cancer progression.
Joanna Y. Lee,Jessica Chang,Antonia A. Dominguez,Hong-pyo Lee,Sungmin Nam,Julie Chang,Sushama Varma,Lei S. Qi,Robert B. West,Ovijit Chaudhuri +9 more
TL;DR: It is established that YAP does not mediate mechanotransduction in breast cancer, and mechanical signals are transduced independently of YAP, questioning YAP as a therapeutic target.