P
P. Jeremy Wang
Researcher at University of Pennsylvania
Publications - 53
Citations - 3757
P. Jeremy Wang is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Meiosis & Germ cell. The author has an hindex of 26, co-authored 52 publications receiving 3053 citations. Previous affiliations of P. Jeremy Wang include Howard Hughes Medical Institute & Nanjing Medical University.
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Journal ArticleDOI
An abundance of X-linked genes expressed in spermatogonia
P. Jeremy Wang,P. Jeremy Wang,John R. McCarrey,Fang Yang,Fang Yang,David C. Page,David C. Page +6 more
TL;DR: The findings indicate that the X chromosome has a predominant role in pre-meiotic stages of mammalian spermatogenesis, and hypothesize that theX chromosome acquired this prominent role in male germ-cell development as it evolved from an ordinary, unspecialized autosome.
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Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development.
Seth D. Kasowitz,Jun Ma,Stephen J. Anderson,N. Adrian Leu,Yang Xu,Brian D. Gregory,Richard M. Schultz,Richard M. Schultz,P. Jeremy Wang +8 more
TL;DR: It is shown that the nuclear m6A reader YTHDC1 is essential for embryo viability and germline development in mouse and plays a critical role in processing of pre-mRNA transcripts in the oocyte nucleus.
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Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis.
Fang Yang,Rabindranath De La Fuente,N. Adrian Leu,Claudia Baumann,K. John McLaughlin,P. Jeremy Wang +5 more
TL;DR: Strikingly, the mutant SYCP2 protein localizes to axial chromosomal cores in both spermatocytes and fetal oocytes, but SYCP3 does not, demonstrating that SY CP2 is a primary determinant of AEs/LEs and, thus, is required for the incorporation of SY CP3 into SCs.
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Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis.
Yong-Hyun Shin,Youngsok Choi,Serpil Uckac Erdin,Svetlana A. Yatsenko,Malgorzata Kloc,Fang Yang,P. Jeremy Wang,Marvin L. Meistrich,Aleksandar Rajkovic,Aleksandar Rajkovic +9 more
TL;DR: Hormad1 deficiency abolishes γH2AX, ATR, and BRCA1 localization to the sex chromosomes and causes transcriptional de-repression on the X chromosome, and HORMAD1 is therefore a critical component of the synaptonemal complex that affects synapsis, recombination, and meiotic sex chromosome inactivation and transcriptional silencing.
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The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing
Anastassios Vourekas,Ke Zheng,Qi Fu,Manolis Maragkakis,Panagiotis Alexiou,Jing Ma,Ramesh S. Pillai,Zissimos Mourelatos,P. Jeremy Wang +8 more
TL;DR: The results support a model in which MOV10L1 RNA helicase activity promotes unwinding and funneling of the single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing.