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Brian D. Gregory
Researcher at University of Pennsylvania
Publications - 134
Citations - 10564
Brian D. Gregory is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: RNA & Nucleic acid secondary structure. The author has an hindex of 46, co-authored 124 publications receiving 8911 citations. Previous affiliations of Brian D. Gregory include University of Maryland, Baltimore County & University of Arizona.
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Journal ArticleDOI
Highly Integrated Single-Base Resolution Maps of the Epigenome in Arabidopsis
Ryan Lister,Ronan C. O'Malley,Julian Tonti-Filippini,Brian D. Gregory,Charles C. Berry,A. Harvey Millar,Joseph R. Ecker +6 more
TL;DR: Deep sequencing of smRNAs revealed a direct relationship between the location of sm RNAs and DNA methylation, perturbation of smRNA biogenesis upon loss of CpG DNA methylisation, and a tendency for smRN as to direct strand-specific DNA methylations in regions of RNA-DNA homology.
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Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
Parisha P. Shah,Greg Donahue,Gabriel L. Otte,Brian C. Capell,David M. Nelson,Kajia Cao,Varun Aggarwala,Hazel A Cruickshanks,Taranjit Singh Rai,Tony McBryan,Brian D. Gregory,Peter D. Adams,Shelley L. Berger +12 more
TL;DR: Comparing genome-wide Lys4 trimethylation on histone H3 and H3K27me3 distributions between proliferating and senescent human cells found dramatic differences in senescence, suggesting that pre-malignant senescent chromatin changes foreshadow epigenetic cancer changes.
Journal ArticleDOI
A link between RNA metabolism and silencing affecting Arabidopsis development.
Brian D. Gregory,Ronan C. O'Malley,Ryan Lister,Mark A. Urich,Julian Tonti-Filippini,Huaming Chen,A. Harvey Millar,Joseph R. Ecker +7 more
TL;DR: The results reveal unexpected connections between RNA metabolism and silencing pathways and suggest that uncapped endogenous transcripts can become smRNA biogenesis substrates.
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Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development.
Seth D. Kasowitz,Jun Ma,Stephen J. Anderson,N. Adrian Leu,Yang Xu,Brian D. Gregory,Richard M. Schultz,Richard M. Schultz,P. Jeremy Wang +8 more
TL;DR: It is shown that the nuclear m6A reader YTHDC1 is essential for embryo viability and germline development in mouse and plays a critical role in processing of pre-mRNA transcripts in the oocyte nucleus.
Journal ArticleDOI
Genome-Wide High-Resolution Mapping of Exosome Substrates Reveals Hidden Features in the Arabidopsis Transcriptome
Julia A. Chekanova,Julia A. Chekanova,Brian D. Gregory,Sergei V. Reverdatto,Huaming Chen,Ravi Kumar,Tanya Hooker,Junshi Yazaki,Pinghua Li,Nikolai P. Skiba,Qian Peng,Qian Peng,Jose M. Alonso,Vladimir Brukhin,Ueli Grossniklaus,Joseph R. Ecker,Dmitry A. Belostotsky,Dmitry A. Belostotsky +17 more
TL;DR: It is demonstrated that as opposed to yeast and metazoans the plant exosome core possesses an unanticipated functional plasticity and a genome-wide atlas of Arabidopsis exosomes targets is presented, which will aid in illuminating new fundamental components and regulatory mechanisms of eukaryotic transcriptomes.