J. Appl. Cryst.の発刊に際して

10. Patented Literature 2616 10.1. Esterification 2616 10.2. Ether Formation 2619 10.2.1. Etherification without Cyclization 2619 10.2.2. Etherification with Cyclization 2624 10.3. N-Alkylation 2625 10.4. Other Reactions 2627 11. Summary and Outlook 2628 12. Note Added in Proof 2628 13. Abbreviations Used in This Review 2629 14. Acknowledgments 2629 15. Supporting Information Available 2630 16. References 2630

Mitsunobu and Related Reactions: Advances and Applications

The Complementary Competitors: Palladium and Copper in C-N Cross-Coupling Reactions

Green synthesis of silver nanoparticles using Alternanthera dentata leaf extract at room temperature and their antimicrobial activity

Cover -- Advancesin Heterocyclic Chemistry13; -- Copyright Page -- Contents -- Contributors -- Preface13; -- Chapter 113; Hexameric Macrocyclic Architectures in Heterocyclic Chemistry -- 1. Introduction -- 2. Macrocycles with Five-Membered Heterocyclic Subunits -- 3. Six-Membered Ring Heterocycles -- 4. Miscellaneous Heterocyclic Materials -- 5. Conclusions -- References -- Chapter 2 13;Metal-Catalyzed Intramolecular Heteroatom (X)!Carbon(C) Functional Group Migration Reactions Involving Additionsof X2;Y Bonds Across Alkynes -- 1. Introduction -- 2. Synthesis of O-Containing Heterocycles -- 3. Synthesis of N-Containing Heterocycles -- 4. Synthesis of S-Containing Heterocycles -- 5. Synthesis of Se-Containing Heterocycles -- 6. Conclusions -- Acknowledgments -- References -- Chapter 313; Biindolyls -- 1. Introduction -- 2. Synthesis -- 3. Reactions -- 4. Conclusion -- References -- Chapter 413; The Annulation of 2-Imidazolines -- 1. Introduction -- 2. Polar Annulation Strategy -- 3. Imidazolines as Double Nucleophiles -- 4. Annulations of the Enamino Ester/Ketene Aminal -- 5. Annulations of N-Unsubstituted 2-Imidazolines -- 6. Imidazolines as Sources of 1,3-Dipoles -- 7. Azomethine Ylides by Alkylation2;Deprotonation -- 8. Azomethine Ylides by Carbene Insertion in a Catalytic Cycle -- 9. Azomethine Ylides by Conjugate Addition-Proton Transfer -- 10. Annulations Using Chiral Imidazolines -- 11. Optically Active Piperidines via Enamino Ester Annulation -- 12. Dipolar Cycloaddition of Optically Active Imidazolinium Ylides -- 13. Chiral Imidazoline Nitrones in Cycloadditions -- 14. Summary -- References -- Chapter 5 Recent Advances in the Dimroth Rearrangement: A ValuableTool for the Synthesis of Heterocycles -- 1. Introduction -- 2. Translocation of Heteroatoms in Fused Heterocycles (Type 1) -- 3. Translocation of Exo- and Endocyclic Heteroatoms in Heterocycles(Type 2) -- Acknowledgments -- References -- Subject Index.

Advances in Heterocyclic Chemistry

In the title mol­ecule, C22H21N3, the isoquinoline ring is almost planar [maximum deviation = 0.046 (1) A] and makes dihedral angles of 52.01 (4) and 14.61 (4)° with the pyrazole and phenyl rings, respectively. The phenyl ring and the pyrazole ring are twisted by 44.20 (6)° with respect to each other. The terminal C atoms of both of the ethyl groups attached to the pyrazole ring are disordered over two sites with occupancy ratios of 0.164 (7):0.836 (7) and 0.447 (16):0.553 (16). A weak intra­molecular C—H⋯N contact may influence the mol­ecular conformation. The crystal structure is stabilized by C—H⋯π contacts involving the phenyl and pyrazole rings, and by π–π stacking inter­actions involving the pyridine and benzene rings [centroid–centroid distance = 3.5972 (10) A].

https://journals.iucr.org/e/issues/2009/08/00/bt2974/bt2974.pdf

1-(3,5-Diethyl-1H-pyrazol-1-yl)-3-phenyl­isoquinoline

N-substituted pyrazoles, pyrroles, and pyrazolones have been synthesized from 1,3 diketones, 1,4 diketones or α-haloesters, and hydrazinoisoquinolines. Reaction occurred at room temperature and furnished the desired products in excellent yields. The structures of the synthesized products were confirmed spectroscopically, including use of one dimensional 1H and 13C NMR spectroscopy and two-dimensional H,H-COSY and C,H-COSY. The antioxidant activity of the pyrazoles was evaluated and compared with that of the standard antioxidant BHT. .

Synthesis, structure determination, and antioxidant activity of novel 1-pyrazolyl-3-substituted isoquinolines, 1-pyrrolyl 3-substituted isoquinolin-1-amine, and 1-pyrazolonyl-substituted isoquinolines

In the title mol­ecule, C22H14ClN3, the triazoloisoquinoline ring system is approximately planar, with an r.m.s. deviation of 0.033 (2) A and a maximum departure from the mean plane of 0.062 (1) A for the triazole ring C atom, bonded to the benzene ring. The benzene and phenyl rings are twisted by 57.02 (6) and 62.16 (6)°, respectively, to the mean plane of the triazoloisoquinoline ring system. The mol­ecule is stabilized by a weak intra­molecular π–π inter­action [centroid–centroid distance = 3.7089 (10) A] between the benzene and phenyl rings. In the crystal structure, weak inter­molecular C—H⋯N hydrogen bonds and C—H⋯π inter­actions link the mol­ecules.

https://journals.iucr.org/e/issues/2010/05/00/bg2341/bg2341.pdf

3-(4-Chloro­phen­yl)-5-phenyl-1,2,4-triazolo[3,4-a]isoquinoline

The title compound, C15H11NO, consists of a planar isoquinolinone group to which a phenyl ring is attached in a twisted fashion [dihedral angle = 39.44 (4)°]. The crystal packing is dominated by inter­molecular N—H⋯O and C—H⋯O hydrogen bonds which define centrosymmetric dimeric entitities.

/pdf/3-phenyl-isoquinolin-1-2h-one-40lfhx99aw.pdf

3-Phenyl-isoquinolin-1(2H)-one.

A facile and microwave accelerated reaction of 1-chloro-3-(4-chlorophenyl)isoquinoline with various heterocyclic amines, catalyzed by Pd, in the presence of BINAP additive and sodium carbonate as the base, leads to the formation of 3-(4-chlorophenyl)-1-(1H-1,2,3-triazol-1-yl)isoquinoline, 3-(4-chlorophenyl)-1-(1H-imidazol-1-yl)isoquinoline and 3-(4-chlorophenyl)-1-(1H-1,2,4-triazol-1-yl)isoquinoline via Buchwald protocol in good yields. Similarly pyrazolylisoquinolines are also reported.

An Effective BINAP‐ and Microwave‐Accelerated Palladium‐Catalyzed Amination of 1‐Chloroisoquinolines in the Synthesis of New 1,3‐Disubstituted Isoquinolines.

P. Manivel

Papers

1-(3,5-Diethyl-1H-pyrazol-1-yl)-3-phenylisoquinoline

Synthesis, structure determination, and antioxidant activity of novel 1-pyrazolyl-3-substituted isoquinolines, 1-pyrrolyl 3-substituted isoquinolin-1-amine, and 1-pyrazolonyl-substituted isoquinolines

3-(4-Chlorophenyl)-5-phenyl-1,2,4-triazolo[3,4-a]isoquinoline

3-Phenyl-isoquinolin-1(2H)-one.

An Effective BINAP‐ and Microwave‐Accelerated Palladium‐Catalyzed Amination of 1‐Chloroisoquinolines in the Synthesis of New 1,3‐Disubstituted Isoquinolines.

P. Manivel

Papers

1-(3,5-Diethyl-1H-pyrazol-1-yl)-3-phenyl­isoquinoline

Synthesis, structure determination, and antioxidant activity of novel 1-pyrazolyl-3-substituted isoquinolines, 1-pyrrolyl 3-substituted isoquinolin-1-amine, and 1-pyrazolonyl-substituted isoquinolines

3-(4-Chloro­phen­yl)-5-phenyl-1,2,4-triazolo[3,4-a]isoquinoline

3-Phenyl-isoquinolin-1(2H)-one.

An Effective BINAP‐ and Microwave‐Accelerated Palladium‐Catalyzed Amination of 1‐Chloroisoquinolines in the Synthesis of New 1,3‐Disubstituted Isoquinolines.

1-(3,5-Diethyl-1H-pyrazol-1-yl)-3-phenylisoquinoline

3-(4-Chlorophenyl)-5-phenyl-1,2,4-triazolo[3,4-a]isoquinoline