P
P. W. Collins
Researcher at G. D. Searle & Company
Publications - 8
Citations - 2115
P. W. Collins is an academic researcher from G. D. Searle & Company. The author has contributed to research in topics: Trifluoromethyl & Binding site. The author has an hindex of 4, co-authored 8 publications receiving 2001 citations.
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Journal ArticleDOI
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
T. D. Penning,John J. Talley,Bertenshaw,Jeffery S. Carter,P. W. Collins,Stephen H. Docter,Matthew J. Graneto,Len F. Lee,James W. Malecha,Julie M. Miyashiro,Roland S. Rogers,D. J. Rogier,Stella S. Yu,AndersonGD,E. G. Burton,J. N. Cogburn,Susan A. Gregory,Carol M. Koboldt,W E Perkins,Karen Seibert,A. W. Veenhuizen,Yan Y. Zhang,P. C. Isakson +22 more
TL;DR: 1i (4-[5-(4-methylphenyl)-3-(trifluoromethyl)- H-pyrazol-1-yl]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis, is identified.
Journal ArticleDOI
Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-(5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide (SC-58635, Celecoxib).
T. D. Penning,J. J. Tallay,Stephen R. Bertenshaw,Jeffery S. Carter,P. W. Collins,Stephen H. Docter,Matthew J. Graneto,Len F. Lee,James W. Malecha,Julie M. Miyashiro +9 more
Journal ArticleDOI
7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4-dihydro-8- propyl-2H-1-benzopyran-2-carboxylic acid: an orally active selective leukotriene B4 receptor antagonist.
S. W. Djuric,P. W. Collins,Jones Ph,R. L. Shone,B.S. Tsai,D. J. Fretland,Butchko Gm,D Villani-Price,R H Keith,J. M. Zemaitis +9 more
Journal ArticleDOI
Catalytic functionalization of polymers : a novel approach to site specific delivery of misoprostol to the stomach
Samuel J. Tremont,P. W. Collins,W E Perkins,Ricky L. Fenton,Denis Forster,M. P. McGrath,G. M. Wagner,Alan F. Gasiecki,R. G. Bianchi,J J Casler +9 more
TL;DR: The diisopropylsilyl analog, the slowest releasing system studied, showed efficacy equal to misoprostol against indomethacin-induced gastric damage and no diarrhea at the highest dose tested.
Journal ArticleDOI
Synthesis and structure-activity relationships of acyclic omega chain conjugated diene analogues of enisoprost.
P. W. Collins,Robert L. Shone,W E Perkins,Alan F. Gasiecki,V. J. Kalish,Steven W. Kramer,R. G. Bianchi +6 more
TL;DR: It appears that both the conjugated diene and the overall space filling characteristics of the omega chain are important components to the pharmacological profiles and selectivity of these compounds and that a cyclic structure is not required.