P
Pakorn Kanchanawong
Researcher at National University of Singapore
Publications - 59
Citations - 3771
Pakorn Kanchanawong is an academic researcher from National University of Singapore. The author has contributed to research in topics: Actin cytoskeleton & Focal adhesion. The author has an hindex of 18, co-authored 50 publications receiving 3169 citations. Previous affiliations of Pakorn Kanchanawong include Stanford University & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Nanoscale architecture of integrin-based cell adhesions
Pakorn Kanchanawong,Gleb Shtengel,Ana Maria Pasapera,Ericka B. Ramko,Michael W. Davidson,Harald F. Hess,Clare M. Waterman +6 more
TL;DR: Three-dimensional super-resolution fluorescence microscopy is used to map nanoscale protein organization in focal adhesions and reveals talin’s polarized orientation, indicative of a role in organizing the focal adhesion strata.
Journal ArticleDOI
Interferometric fluorescent super-resolution microscopy resolves 3D cellular ultrastructure
Gleb Shtengel,James A. Galbraith,Catherine G. Galbraith,Jennifer Lippincott-Schwartz,Jennifer M. Gillette,Suliana Manley,Rachid Sougrat,Clare M. Waterman,Pakorn Kanchanawong,Michael W. Davidson,Richard D. Fetter,Harald F. Hess +11 more
TL;DR: iPALM closes the gap between electron tomography and light microscopy, enabling both molecular specification and resolution of cellular nanoarchitecture.
Journal ArticleDOI
Actin-Delimited Adhesion-Independent Clustering of E-Cadherin Forms the Nanoscale Building Blocks of Adherens Junctions
TL;DR: It is found that loosely organized clusters of approximately five E-cadherin molecules that form independently of cis or trans interactions, and that are delimited by the cortical F-actin meshwork, are the precursors of trans-ligated adhesive clusters that make up the adherens junction.
Journal ArticleDOI
Talin determines the nanoscale architecture of focal adhesions
Jaron Liu,Yilin Wang,Wah Ing Goh,Honzhen Goh,Michelle A. Baird,Svenja Ruehland,Shijia Teo,Neil Bate,David R. Critchley,Michael W. Davidson,Pakorn Kanchanawong +10 more
TL;DR: It is demonstrated that talin plays a key structural role in regulating the nanoscale architecture of FAs, akin to a molecular ruler, in a remarkably modular manner.
Journal ArticleDOI
Nanoscale architecture of cadherin-based cell adhesions
Cristina Bertocchi,Yilin Wang,Andrea Ravasio,Yusuke Hara,Yao Wu,Talgat Sailov,Michelle A. Baird,Michael W. Davidson,Ronen Zaidel-Bar,Yusuke Toyama,Benoit Ladoux,René-Marc Mège,Pakorn Kanchanawong +12 more
TL;DR: Modular architecture provides a structural framework for mechanical and biochemical signal integration by vinculin, which may differentially engage cadherin–catenin complexes with the actomyosin machinery to regulate cell adhesions.