Pál Gergely

TL;DR: The structure of GPb-TH complex reveals that the inhibitor can be accommodated in the catalytic site of T-state GPb with very little change of the tertiary structure, and provides a basis of understanding potency and specificity of the inhibitor.

TL;DR: The results demonstrate that NO(-)/HNO-induced PARP activation shifts the default apoptotic cell death toward necrosis in thymocytes, however, as total PARP inhibition resulted only in 30% cytoprotection, PARP-independent mechanisms dominate NO (-)/H NO-induced cytotoxicity inThymocytes.

TL;DR: Co-ordinated regulation of glycogen phosphorylase and synthase is demonstrated by 50 µM TH in liver extracts of Wistar rats, resulting in the activation of synthase by a shortening of the latency compared to control animals, which was effective in lowering blood glucose levels and restoring hepatic glycogen content in streptozotocin-induced diabetic rats.

TL;DR: It is demonstrated that PP2A plays a role in the regulation of the PKA signaling pathway and that the phosphorylation level of CREB is influenced by the activity of both enzymes during in vitro chondrogenesis.

TL;DR: Results indicate that OA induces differential phosphorylation and translocation of MYPT1, dependent on PP2A and, to varying extents, on ROK, associated with an increased level of myosin II phosphorylated and attenuation of hepatic cell migration.