P
Pál Gergely
Researcher at University of Debrecen
Publications - 200
Citations - 6031
Pál Gergely is an academic researcher from University of Debrecen. The author has contributed to research in topics: Glycogen phosphorylase & Phosphorylase kinase. The author has an hindex of 42, co-authored 199 publications receiving 5643 citations. Previous affiliations of Pál Gergely include Hungarian Academy of Sciences & Novartis.
Papers
More filters
Journal ArticleDOI
3-Aminobenzamide protects primary human keratinocytes from UV-induced cell death by a poly(ADP-ribosyl)ation independent mechanism.
Petra Lakatos,Éva Szabó,Csaba Hegedűs,Csaba Hegedűs,György Haskó,Pál Gergely,Pál Gergely,Péter Bai,Péter Bai,László Virág,László Virág +10 more
TL;DR: It is found that 3-aminobenzamide is photoprotective and acts by a PARP-independent mechanism at a premitochondrial step of phototoxicity and is a survival mechanism in UV-treated keratinocytes.
Journal ArticleDOI
Calcineurin regulates endothelial barrier function by interaction with and dephosphorylation of myosin phosphatase
Bernadett Kolozsvári,Éva Bakó,Bálint Bécsi,Bálint Bécsi,Andrea Kiss,Agnes Czikora,Attila Tóth,György Vámosi,Pál Gergely,Ferenc Erdődi,Ferenc Erdődi +10 more
TL;DR: CN may improve endothelial barrier function via inducing dephosphorylation of cofilin(pSer3) and by interaction withMYPT1 and activating MP through MYPT1(pThr696) deph phosphatelation, thereby affecting actin polymerization and decreasing myosin phosphorylation.
Journal ArticleDOI
Tethered derivatives of D-glucose and pentacyclic triterpenes for homo/heterobivalent inhibition of glycogen phosphorylase
Keguang Cheng,Jun Liu,Hongbin Sun,Éva Bokor,Katalin Czifrák,Bálint Kónya,Marietta Tóth,Tibor Docsa,Pál Gergely,László Somsák +9 more
TL;DR: Propargyl esters of the C-28 carboxylic acids of pentacyclic triterpenes were coupled with 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl azide as well as N-(ω-azido-[C-2, C-6, and C-11]alkanoyl)-β- D-glUCopyrnosylamines under conditions of
Journal ArticleDOI
Synthesis of 1,2,3-triazoles from xylosyl and 5-thioxylosyl azides: evaluation of the xylose scaffold for the design of potential glycogen phosphorylase inhibitors
David Goyard,Marc Baron,Paraskevi V. Skourti,Aikaterini S. Chajistamatiou,Tibor Docsa,Pál Gergely,Evangelia D. Chrysina,Jean Pierre Praly,Sébastien Vidal +8 more
TL;DR: Deacetylation afforded 19 hydroxylated xylose and 5-thioxylose derivatives, found to be only sparingly water-soluble and much weaker inhibitors of glycogen phosphorylase than glucose-based analogues.
Journal ArticleDOI
Crystallographic Studies on α- and β-D-glucopyranosyl Formamide Analogues, Inhibitors of Glycogen Phosphorylase
Evangelia D. Chrysina,Nikos G. Oikonomakos,Spyros E. Zographos,Magda Kosmopoulou,Nicolas Bischler,Demetres D. Leonidas,Laszlo Kovacs,Tibor Docsa,Pál Gergely,László Somsák +9 more
TL;DR: In this article, three D-glucopyranosyl analogues, C-(1-azido-α-D-GLU-glU-poly(1-acetamido)-α,D-glUCU-DGLU(1)-formamide, and C-( 1-hydroxy-β-DglU-, β-DG-glugopyranoyl) formamide, were recognized as moderate competitive inhibitors of muscle GPb with Ki values of 1.80 (± 0.2) mM, 0.31