P
Pál Gergely
Researcher at University of Debrecen
Publications - 200
Citations - 6031
Pál Gergely is an academic researcher from University of Debrecen. The author has contributed to research in topics: Glycogen phosphorylase & Phosphorylase kinase. The author has an hindex of 42, co-authored 199 publications receiving 5643 citations. Previous affiliations of Pál Gergely include Hungarian Academy of Sciences & Novartis.
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Journal ArticleDOI
In Search of Glycogen Phosphorylase Inhibitors: 5-Substituted 3-C-Glucopyranosyl-1,2,4-oxadiazoles from β-D-Glucopyranosyl Cyanides upon Cyclization of O-Acylamidoxime Intermediates
Mahmoud Benltifa,Sébastien Vidal,Bernard Fenet,Moncef Msaddek,Peter G. Goekjian,Jean Pierre Praly,Attila Brunyanszki,Tibor Docsa,Pál Gergely +8 more
TL;DR: In this paper, a 5-substituted 3-C-β-D-glucopyranosyl-1,2,4-oxadiazole was obtained for the first time.
Journal ArticleDOI
Synthesis of N-(β-D-glucopyranosyl)- and N-(2-acetamido-2-deoxy-β-D-glucopyranosyl) amides as inhibitors of glycogen phosphorylase
Zoltán Györgydeák,Zsuzsa Hadady,Nóra Felföldi,Attila Krakomperger,Veronika Nagy,Marietta Tóth,Attila Brunyanszki,Tibor Docsa,Pál Gergely,László Somsák +9 more
TL;DR: In this article, the deprotected compounds obtained by Zemplen deacetylation were evaluated as inhibitors of rabbit muscle glycogen phosphorylase b. The best inhibitor has been N -(β- D -glucopyranosyl) 3-(2-naphthyl)-propenoic amide (K i ǫ = 3.5μM).
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Endothall thioanhydride inhibits protein phosphatases-1 and -2A in vivo
TL;DR: The potency sequence of ETA > CA > endothall > ETA was established for the inhibition of PP1 and PP2A in vivo and shows close correlation with the sequence of relative toxicity.
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Synthesis of variously coupled conjugates of D-glucose, 1,3,4-oxadiazole, and 1,2,3-triazole for inhibition of glycogen phosphorylase
Sándor Kun,Gergő Zoltán Nagy,Marietta Tóth,Laura Czecze,Albert Nguyen Van Nhien,Tibor Docsa,Pál Gergely,Maria Despoina Charavgi,Paraskevi V. Skourti,Evangelia D. Chrysina,Tamás Patonay,László Somsák +11 more
TL;DR: 5-Phenyltetrazole was transformed into 5-ethynyl- as well as 5-chloromethyl-2-(O-perbenzoylated-β-D-glucopyranosyl)-1,3,4-oxadiazoles by acylation with propiolic acid-DCC or chloroacetyl chloride by the Zemplén protocol.
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Dephosphorylation of distinct sites on microtubule-associated protein MAP1B by protein phosphatases 1, 2A and 2B
Luis Ulloa,Viktor Dombrádi,Javier Díaz-Nido,Kornélia Szücs,Pál Gergely,Peter Friedrich,Jesús Avila +6 more
TL;DR: The selectivity of phosphatases for different sites within the same protein indicates the complexity of the dephosphorylation reactions regulating the functionality of MAP1B in neurons.