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Pamela Blaikie
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 5
Citations - 2551
Pamela Blaikie is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Phosphorylation & Neovascularization. The author has an hindex of 5, co-authored 5 publications receiving 2481 citations.
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Journal ArticleDOI
Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
David Lyden,Koichi Hattori,Koichi Hattori,Sergio Dias,Carla Costa,Pamela Blaikie,Linda J. Butros,Amy Chadburn,Beate Heissig,Willy Marks,Larry Witte,Yan Wu,Daniel J. Hicklin,Zhenping Zhu,Neil R. Hackett,Ronald G. Crystal,Malcolm A.S. Moore,Katherine A. Hajjar,Katia Manova,Robert Benezra,Shahin Rafii +20 more
TL;DR: It is demonstrated that recruitment of VEGF-responsive BM-derived precursors is necessary and sufficient for tumor angiogenesis and suggested new clinical strategies to block tumor growth are suggested.
Journal ArticleDOI
Integrin β4 signaling promotes tumor angiogenesis
TL;DR: Genetic evidence is provided that α6β4 signaling promotes the onset of the invasive phase of pathological angiogenesis and hence identifies a novel target for antiangiogenic therapy.
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Tyrosine Phosphorylation of the β4 Integrin Cytoplasmic Domain Mediates Shc Signaling to Extracellular Signal-regulated Kinase and Antagonizes Formation of Hemidesmosomes
Michael Dans,Laurent Gagnoux-Palacios,Pamela Blaikie,Sharon Klein,Agnese Mariotti,Filippo G. Giancotti +5 more
TL;DR: It is suggested that β4 Tyr1526 interacts in a phosphorylation-dependent manner with the PTB domain of Shc, which is required for subsequent tyrosine phosphorylated protein Shc and signaling to ERK but not formation of hemidesmosomes.
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α5β1 Integrin Activates an NF-κB-Dependent Program of Gene Expression Important for Angiogenesis and Inflammation
Sharon Klein,Antonin R. de Fougerolles,Pamela Blaikie,Leila Khan,Angela Pepe,Cynthia Green,Victor Koteliansky,Filippo G. Giancotti +7 more
TL;DR: GeneCalling suggests that engagement of the α5β1 integrin promotes an NF-κB-dependent program of gene expression that coordinately regulates angiogenesis and inflammation.
Journal ArticleDOI
Targeted Deletion of the Integrin β4 Signaling Domain Suppresses Laminin-5-Dependent Nuclear Entry of Mitogen-Activated Protein Kinases and NF-κB, Causing Defects in Epidermal Growth and Migration
Sotiris N. Nikolopoulos,Pamela Blaikie,Toshiaki Yoshioka,Wenjun Guo,Claudia Puri,Carlo Tacchetti,Filippo G. Giancotti +6 more
TL;DR: Evidence is provided that β4 signaling promotes epidermal growth and wound healing through a previously unrecognized effect on nuclear translocation of NF-κB and mitogen-activated protein kinases.