Y
Yan Wu
Researcher at ImClone Systems
Publications - 70
Citations - 14290
Yan Wu is an academic researcher from ImClone Systems. The author has contributed to research in topics: Vascular endothelial growth factor & Angiogenesis. The author has an hindex of 38, co-authored 66 publications receiving 13622 citations. Previous affiliations of Yan Wu include Eli Lilly and Company & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Rosandra N. Kaplan,Rebecca D. Riba,Stergios Zacharoulis,Anna H. Bramley,Loic Vincent,Carla Costa,Daniel D. MacDonald,David K. Jin,Koji Shido,Scott A. Kerns,Zhenping Zhu,Daniel J. Hicklin,Yan Wu,Jeffrey L. Port,Nasser K. Altorki,Elisa Port,Davide Ruggero,Sergey V. Shmelkov,Kristian K. Jensen,Shahin Rafii,David Lyden +20 more
TL;DR: A requirement for VEGFR1+ haematopoietic progenitor cells that express vascular endothelial growth factor receptor 1 (VEGFR1) home to tumour-specific pre-metastatic sites and form cellular clusters before the arrival of tumour cells is demonstrated.
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Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
David Lyden,Koichi Hattori,Koichi Hattori,Sergio Dias,Carla Costa,Pamela Blaikie,Linda J. Butros,Amy Chadburn,Beate Heissig,Willy Marks,Larry Witte,Yan Wu,Daniel J. Hicklin,Zhenping Zhu,Neil R. Hackett,Ronald G. Crystal,Malcolm A.S. Moore,Katherine A. Hajjar,Katia Manova,Robert Benezra,Shahin Rafii +20 more
TL;DR: It is demonstrated that recruitment of VEGF-responsive BM-derived precursors is necessary and sufficient for tumor angiogenesis and suggested new clinical strategies to block tumor growth are suggested.
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Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
Peter Carmeliet,Lieve Moons,Aernout Luttun,Valeria Vincenti,Veerle Compernolle,Maria De Mol,Yan Wu,Françoise Bono,Laetitia Devy,Heike Beck,Dimitri Scholz,Till Acker,Tina DiPalma,Mieke Dewerchin,Agnès Noël,Ingeborg Stalmans,Adriano Barra,S. Blacher,Thierry VandenDriessche,Annica Pontén,Ulf Eriksson,Karl H. Plate,Jean-Michel Foidart,Wolfgang Schaper,D. Stephen Charnock-Jones,Daniel J. Hicklin,Jean-Marc Herbert,Desire Collen,M. Graziella Persico +28 more
TL;DR: It is reported that embryonic angiogenesis in mice was not affected by deficiency of PlGF, andTransplantation of wild-type bone marrow rescued the impairedAngiogenesis and collateral growth in Pgf−/− mice, indicating that PlGF might have contributed to vessel growth in the adult by mobilizing bone-marrow–derived cells.
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Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
Aernout Luttun,Marc Tjwa,Lieve Moons,Yan Wu,Anne Angelillo-Scherrer,Francesca-Fang Liao,Janice A. Nagy,Andrea T. Hooper,Josef Priller,Bert De Klerck,Bert De Klerck,Veerle Compernolle,Evis Daci,Peter Bohlen,Mieke Dewerchin,Jean Marc Herbert,Roy A. Fava,Patrick Matthys,Patrick Matthys,Geert Carmeliet,Desire Collen,Harold F. Dvorak,Daniel J. Hicklin,Peter Carmeliet +23 more
TL;DR: PlGF stimulated angiogenesis and collateral growth in ischemic heart and limb with at least a comparable efficiency to vascular endothelial growth factor (VEGF) and an antibody against Flt1 suppressed neovascularization in tumors and isChemic retina, and angiogenic and inflammatory joint destruction in autoimmune arthritis.
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Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1 + stem cells from bone-marrow microenvironment
Koichi Hattori,Beate Heissig,Yan Wu,Sergio Dias,Rafael Tejada,Barbara Ferris,Daniel J. Hicklin,Zhenping Zhu,Peter Bohlen,Larry Witte,Jan Hendrikx,Neil R. Hackett,Ronald G. Crystal,Malcolm A.S. Moore,Zena Werb,David Lyden,David Lyden,Shahin Rafii +17 more
TL;DR: Functional vascular endothelial growth factor receptor-1 (VEGFR1) is expressed on human CD34+ and mouse Lin−Sca-1+c-Kit+ BM-repopulating stem cells, conveying signals for recruitment of HSCs and reconstitution of hematopoiesis.