P
Pamela J. Smolak
Researcher at Amgen
Publications - 8
Citations - 5128
Pamela J. Smolak is an academic researcher from Amgen. The author has contributed to research in topics: Gene & Receptor. The author has an hindex of 7, co-authored 7 publications receiving 5026 citations.
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Journal ArticleDOI
Identification and characterization of a new member of the TNF family that induces apoptosis
Steven R. Wiley,Ken Schooley,Pamela J. Smolak,Wenie S. Din,Chang-Pin Huang,Jillian Nicholl,Grant R. Sutherland,Terri Davis Smith,Charles Rauch,Craig A. Smith,Raymond G. Goodwin +10 more
TL;DR: A novel tumor necrosis factor (TNF) family member has been cloned and characterized, and the TRAIL gene is located on chromosome 3 at position 3q26, which is not close to any other known TNF ligand family members.
Journal ArticleDOI
The Novel Receptor TRAIL-R4 Induces NF-κB and Protects against TRAIL-Mediated Apoptosis, yet Retains an Incomplete Death Domain
Mariapia A. Degli-Esposti,William C. Dougall,Pamela J. Smolak,Jennifer Y. Waugh,Craig A. Smith,Raymond G. Goodwin +5 more
TL;DR: Transient overexpression of TRAil-R4 in cells normally sensitive to TRAIL-mediated killing confers complete protection, suggesting that one function of TRAilsR4 may be inhibition of TRAIL cytotoxicity.
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Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family.
Mariapia A. Degli-Esposti,Pamela J. Smolak,Henning Walczak,Jennifer Y. Waugh,Chang Pin Huang,Robert F. DuBose,Raymond G. Goodwin,Craig A. Smith +7 more
TL;DR: The structure of TRAIL-R3 is unique when compared to the other TRAIL receptors in that it lacks a cytoplasmic domain and appears to be glycosyl-phosphatidylinositol–linked.
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Poxvirus Genomes Encode a Secreted, Soluble Protein That Preferentially Inhibits β Chemokine Activity yet Lacks Sequence Homology to Known Chemokine Receptors☆
Craig A. Smith,Terri Davis Smith,Pamela J. Smolak,Della Friend,Heidi Hagen,Mary Gerhart,Linda Park,David J. Pickup,Dauphine Torrance,Ken Mohler,Ken Schooley,Raymond G. Goodwin +11 more
TL;DR: This work shows the "35K" virulence gene in variola and cowpox viruses, whose vaccinia and Shope fibroma virus equivalents are strongly conserved in sequence, actually encodes a secreted soluble protein with high-affinity binding to virtually all known beta chemokines, but only weak or no affinity to the alpha and gamma classes.
Journal ArticleDOI
Cowpox Virus Genome Encodes a Second Soluble Homologue of Cellular TNF Receptors, Distinct from CrmB, That Binds TNF but Not LTα
Craig A. Smith,Fang-Qi Hu,Terri Davis Smith,Cheryl L. Richards,Pamela J. Smolak,Raymond G. Goodwin,David J. Pickup +6 more
TL;DR: The cowpox genome contains a single copy gene, crmC, encoding a soluble, secreted protein whose sequence marks it as a new member of the TNF receptor family, presumed function of CrmC is viral inhibition of host-elicited TNF.