P
Pankaj Gupta
Researcher at National Institutes of Health
Publications - 5
Citations - 41
Pankaj Gupta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: G-quadruplex & Binding site. The author has an hindex of 4, co-authored 5 publications receiving 34 citations.
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Journal ArticleDOI
Preclinical evaluation of a mercaptobenzamide and its prodrug for NCp7-targeted inhibition of human immunodeficiency virus.
Tracy L. Hartman,Lu Yang,A.N. Helfrick,Matthew Hassink,Nathaniel I. Shank,K. George Rosenker,Michael T. Scerba,Mrinmoy Saha,E. Hughes,A.Q. Wang,X. Xu,Pankaj Gupta,Robert W. Buckheit,Daniel H. Appella +13 more
TL;DR: Cell to cell transmission of HIV in multiple passages was significantly reduced in CEM-SS and human PBMCs by reducing progeny virus infectivity at compound concentrations greater than 2 μM, which is consistent with the proposed mechanism of action of the virus inactivating compounds.
Journal ArticleDOI
6-Methoxyethylamino-numonafide inhibits hepatocellular carcinoma xenograft growth as a single agent and in combination with sorafenib.
Yanning Liu,Guohua Lou,John Norton,Chen Wang,Irawati Kandela,Shuai Tang,Nathaniel I. Shank,Pankaj Gupta,Min Huang,Michael J. Avram,Richard M. Green,Andrew P. Mazar,Daniel H. Appella,Zhi Chen,Sui Huang +14 more
TL;DR: 6‐methoxyethylamino‐numonafide (MEAN) is a potent growth inhibitor of murine xenografts of 2 human HCC cell lines and is a promising candidate for clinical development as a single‐agent therapy or in combination with sorafenib for the management of HCC.
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Multivalent LKγ-PNA oligomers bind to a human telomere DNA G-rich sequence to form quadruplexes.
TL;DR: G-quadruplex formation between peptide nucleic acids (PNAs) composed of (L)Kγ-PNA-G monomers and a known portion of human telomeric DNA that adopts three G3 tracts via intramolecular hydrogen bonding is reported.
Journal ArticleDOI
PPG peptide nucleic acids that promote DNA guanine quadruplexes.
Ethan A. Englund,Pankaj Gupta,Christopher M. Micklitsch,Mykola I. Onyshchenko,Evgenia Remeeva,Ronald D. Neumann,Igor G. Panyutin,Daniel H. Appella +7 more
TL;DR: Chemical tools that allow examination of the specific roles of G‐quadruplex formation in vivo, and their association with gene regulation will be essential to understanding the functions of these quadruplexes and might lead to beneficial therapies.
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A click chemistry approach to identify protein targets of cancer chemopreventive phenethyl isothiocyanate
Ying Fu,Lixin Mi,Miloslav Sanda,Shana Silverstein,Monika Aggarwal,Deyun Wang,Pankaj Gupta,Radoslav Goldman,Daniel H. Appella,Fung-Lung Chung +9 more
TL;DR: The identification of protein targets of chemopreventive phenethyl isothiocyanate (PEITC) via "click" chemistry in the A549 human lung cancer cell line is reported, using a novel alkyne-tagged PEITC which was also found to show potent in vitro anticancer activity.