P
Paola B. Arimondo
Researcher at French Institute of Health and Medical Research
Publications - 36
Citations - 1552
Paola B. Arimondo is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Topoisomerase & Oligonucleotide. The author has an hindex of 20, co-authored 36 publications receiving 1454 citations. Previous affiliations of Paola B. Arimondo include Centre national de la recherche scientifique & University of Cape Town.
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Journal ArticleDOI
The triple helix: 50 years later, the outcome
Maria Duca,Pierre Vekhoff,Pierre Vekhoff,Kahina Oussedik,Kahina Oussedik,Ludovic Halby,Ludovic Halby,Paola B. Arimondo,Paola B. Arimondo +8 more
TL;DR: The state of art of the triplex-based anti-gene strategy 50 years after the discovery of such a structure is reported, and the importance of the actual applications and the main challenges that the authors still have ahead of us are shown.
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Thirty years of Escherichia coli DNA gyrase: from in vivo function to single-molecule mechanism.
TL;DR: The biological roles of gyrase in vivo and its mechanism in vitro are reviewed and a unique ability that arises from the specialized C-terminal DNA wrapping domain of the GyrA subunit of type II topoisomerase is described.
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Interaction of human DNA topoisomerase I with G‐quartet structures
Paola B. Arimondo,Jean-François Riou,Jean-Louis Mergny,Jamal Tazi,Jian-Sheng Sun,Thérèse Garestier,Claude Hélène +6 more
TL;DR: It is shown here that human topoisomerase I (Topo I) plays an unexpected role of 'molecular matchmaker' for G-quartet formation, and provides evidence that these complexes are parallel G- Quartet structures, mediated by tetrads of hydrogen-bonded guanine.
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Mechanistic Insights on the Inhibition of C5 DNA Methyltransferases by Zebularine
Christine Champion,Christine Champion,Dominique Guianvarc'h,Catherine Senamaud-Beaufort,Catherine Senamaud-Beaufort,Renata Z. Jurkowska,Albert Jeltsch,Loïc Ponger,Loïc Ponger,Paola B. Arimondo,Paola B. Arimondo,Anne-Laure Guieysse-Peugeot,Anne-Laure Guieysse-Peugeot +12 more
TL;DR: It is confirmed that zebularine exerts its demethylation activity by stabilizing the binding of DNMTs to DNA, hindering the methylation and decreasing the dissociation, thereby trapping the enzyme and preventing turnover even at other sites.
Journal ArticleDOI
Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates.
Paola B. Arimondo,Craig J. Thomas,Kahina Oussedik,Brigitte Baldeyrou,Christine Mahieu,Ludovic Halby,Dominique Guianvarc'h,Amélie Lansiaux,Sidney M. Hecht,Christian Bailly,Carine Giovannangeli +10 more
TL;DR: The results indicate that these conjugates may be further developed to improve chemotherapeutic cancer treatments by targeting topoisomerase I-induced DNA cleavage to appropriately chosen genes.