P
Paola Caruso
Researcher at University of Cambridge
Publications - 11
Citations - 890
Paola Caruso is an academic researcher from University of Cambridge. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 4, co-authored 5 publications receiving 736 citations. Previous affiliations of Paola Caruso include British Heart Foundation & University of Glasgow.
Papers
More filters
Journal ArticleDOI
Dynamic Changes in Lung MicroRNA Profiles During the Development of Pulmonary Hypertension due to Chronic Hypoxia and Monocrotaline
Paola Caruso,Margaret R. MacLean,Raya Khanin,John D. McClure,Elaine Soon,Mark Southgate,Robert A. MacDonald,Jenny A. Greig,Keith Robertson,Rachel Masson,Laura Denby,Yvonne Dempsie,Lu Long,Nicholas W. Morrell,Andy Baker +14 more
TL;DR: It is demonstrated that hypoxia and growth factors implicated in PAH induced similar changes in miRNA expression, and miR-21 downregulation in human lung tissue and serum from patients with idiopathic PAH is confirmed.
Journal ArticleDOI
A Role for miR-145 in Pulmonary Arterial Hypertension Evidence From Mouse Models and Patient Samples
Paola Caruso,Yvonne Dempsie,Hannah Stevens,Robert A. McDonald,Lu Long,Lu Long,Ruifang Lu,Kevin P. White,Kirsty M. Mair,John D. McClure,Mark Southwood,Mark Southwood,Paul D. Upton,Paul D. Upton,Mei Xin,Eva Van Rooij,Eric N. Olson,Nicholas W. Morrell,Nicholas W. Morrell,Margaret R. MacLean,Andrew H. Baker +20 more
TL;DR: In this article, the role of miR-145 in pulmonary arterial hypertension (PAH) was evaluated in mice treated with anti-miRs via measurement of systolic right ventricular pressure, right ventriches hypertrophy, and percentage of remodeled pulmonary arteries.
Journal ArticleDOI
Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.
Paola Caruso,Benjamin J. Dunmore,Kenny Schlosser,Sandra Schoors,Claudia Dos Santos,Carol Perez-Iratxeta,Jessie R. Lavoie,Hui Zhang,Lu Long,Amanda Flockton,Maria G. Frid,Paul D. Upton,Angelo D'Alessandro,Charaka Hadinnapola,Fedir Kiskin,Mohamad Taha,Liam A. Hurst,Mark L. Ormiston,Akiko Hata,Kurt R. Stenmark,Peter Carmeliet,Duncan J. Stewart,Nicholas W. Morrell +22 more
TL;DR: In this paper, the authors examined the miRNA and proteomic profiles of blood outgrowth endothelial cells (BOECs) from patients with heritable pulmonary arterial hypertension (PAH) caused by mutations in the bone morphogenetic protein receptor type 2 (BMPR2) gene and patients with idiopathic PAH to determine mechanisms underlying abnormal endothelial glycolysis.
Journal ArticleDOI
Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis
Hui Zhang,Daren Wang,Min Li,Lydie Plecitá-Hlavatá,Angelo D'Alessandro,Jan Tauber,Suzette R. Riddle,Sushil Kumar,Amanda Flockton,B. Alexandre McKeon,Maria G. Frid,Julie A. Reisz,Paola Caruso,Karim C. El Kasmi,Petr Ježek,Nicholas W. Morrell,Cheng-Jun Hu,Kurt R. Stenmark +17 more
TL;DR: In PH, miR-124 regulates the PKM2/PKM1 ratio, the overall metabolic, proliferative, and inflammatory state of cells, which may open unique therapeutic prospects in targeting the dynamic glycolytic and mitochondrial interactions and between mesenchymal inflammatory cells in PH.
Journal ArticleDOI
BMPR2 Mutation and Metabolic Reprogramming in Pulmonary Arterial Hypertension
TL;DR: In this article , the authors discuss published mechanisms linking metabolic abnormalities with dysfunctional BMPR2 (bone morphogenetic protein receptor 2) signaling; hypothesized mechanistic links requiring further validation; and their relevance to pulmonary arterial hypertension pathogenesis and the development of potential therapeutic strategies.