Paola Rognoni

TL;DR: The data indicate that this nematode-based assay is a promising surrogate model for investigating the heart-specific toxicity of amyloidogenic LCs and for a rapid screening of new therapeutic strategies.

TL;DR: The repertoire of variable region germline genes of λ LC preferentially targeting the heart was characterized and a single gene, IGVL1-44, was found associated with a 5-fold increase in the odds of dominant heart involvement (after adjusting for confounders in a multivariable logistic model).

TL;DR: The authors' data shed light on the architecture of LC amyloids, correlate amino acid sequences with fibril assembly, providing the grounds for development of innovative medicines, and highlight structural motifs that may be common to misfolding-prone LCs.

TL;DR: An unprecedented intrinsic sensitivity of AL PCs to PIs is revealed, even higher than that of MM PCs, associated with distinctive organellar features and expression patterns indicative of cellular stress, and stress-responsive pathways as novel potential therapeutic targets are identified.

TL;DR: It is shown that cardiotoxic LCs establish nonphysiologic protein‐protein contacts in human cardiac cells, offering new clues on the pathogenesis of AL cardiomyopathy.