Francesca Brambilla

TL;DR: It is suggested that CPC- secreted exosomes may be more cardioprotective than BMC-secretedExosomes, and that PAPP-A-mediated IGF-1 release may explain the benefit.

TL;DR: In this article, miR-34a upregulation was transient and preceded aorta mineralization in young and old mice, and calcium quantification revealed that miR34a deficiency reduced soft tissue and aortal medial calcification and the upregulation of the VC Sox9 (SRY [sex-determining region Y]-box 9) and Runx2 and the senescence p16 and p21 markers.

TL;DR: The authors' data shed light on the architecture of LC amyloids, correlate amino acid sequences with fibril assembly, providing the grounds for development of innovative medicines, and highlight structural motifs that may be common to misfolding-prone LCs.

TL;DR: It is shown that histones are also actively released by LPS-activated macrophages in association with extracellular vesicles, making their DNA more accessible and communicating to other cells that infection is present.

TL;DR: The results suggest that endogenous intraoperative cardioprotection in older cardiac surgery patients is early mediated by distinct exosomal proteins regardless of surgery type.