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Paolo Moretti
Researcher at University of Utah
Publications - 64
Citations - 4595
Paolo Moretti is an academic researcher from University of Utah. The author has contributed to research in topics: Medicine & Intellectual disability. The author has an hindex of 28, co-authored 58 publications receiving 4081 citations. Previous affiliations of Paolo Moretti include University of Padua & Baylor College of Medicine.
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Evidence that a complex of sir proteins interacts with the silencer and telomere-binding protein rap1
TL;DR: It is proposed that RAP1 acts in the initiation of transcriptional silencing by recruiting a complex of SIR proteins to the chromosome via protein-protein interactions and is consistent with a model in which SIR3 and SIR4 play a structural role in the maintenance of silent chromatin.
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Learning and Memory and Synaptic Plasticity Are Impaired in a Mouse Model of Rett Syndrome
Paolo Moretti,Jonathan M. Levenson,Fortunato Battaglia,Richard Atkinson,Ryan Teague,Barbara Antalffy,Dawna L. Armstrong,Ottavio Arancio,J. David Sweatt,Huda Y. Zoghbi +9 more
TL;DR: Very early symptomatic Mecp2308/Y mice had increased basal synaptic transmission and deficits in the induction of long-term depression, suggesting that functional and ultrastructural synaptic dysfunction is an early event in the pathogenesis of RTT.
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Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome
TL;DR: The abnormalities of diurnal activity and social behavior in Mecp2(308/Y) mice are reminiscent of the sleep/wake dysfunction and autistic features of RTT, and suggest that MECP2 regulates the expression and/or function of genes involved in social behavior.
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MeCP2 dysfunction in Rett syndrome and related disorders
Paolo Moretti,Huda Y. Zoghbi +1 more
TL;DR: Discovering which genes are misregulated in the absence of functional MeCP2 and demonstrating their role in causing neuronal dysfunction and disease manifestations are challenging but important steps for understanding the pathogenesis of Rett syndrome and related disorders.
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Treatment of wilson disease with ammonium tetrathiomolybdate. IV. Comparison of tetrathiomolybdate and trientine in a double-blind study of treatment of the neurologic presentation of wilson disease
George J. Brewer,Frederick K. Askari,Matthew T. Lorincz,Martha D. Carlson,Michael L. Schilsky,Karen J. Kluin,Peter Hedera,Paolo Moretti,John K. Fink,Roberta M. Tankanow,Robert B. Dick,Julia Sitterly +11 more
TL;DR: Tetrathiomolybdate is a better choice than trientine for preserving neurologic function in patients who present with neurologic disease, and during a 3-year follow-up period were quite good.