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Paresh P. Chothe
Researcher at Vertex Pharmaceuticals
Publications - 32
Citations - 540
Paresh P. Chothe is an academic researcher from Vertex Pharmaceuticals. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 12, co-authored 26 publications receiving 407 citations. Previous affiliations of Paresh P. Chothe include Georgia Regents University & Health Science University.
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Journal ArticleDOI
Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance
Maciej J. Zamek-Gliszczynski,Mitchell E. Taub,Paresh P. Chothe,Xiaoyan Chu,Kathleen M. Giacomini,Richard B. Kim,Adrian S. Ray,Sophie L. Stocker,Jashvant D. Unadkat,Matthias B. Wittwer,Cindy Q. Xia,Sook Wah Yee,Lei Zhang,Yan Zhang +13 more
TL;DR: For the first time, the ITC underscores the importance of transporters involved in drug‐induced vitamin deficiency (THTR2) and those involved in the disposition of biomarkers of organ function (OAT2 and bile acidtransporters).
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Antiapoptotic Properties of α-Crystallin–Derived Peptide Chaperones and Characterization of Their Uptake Transporters in Human RPE Cells
Parameswaran G. Sreekumar,Paresh P. Chothe,K. Krishna Sharma,Rinku Baid,Uday B. Kompella,Christine Spee,Nandini Kannan,Christina Manh,Stephen J. Ryan,Vadivel Ganapathy,Ram Kannan,David R. Hinton +11 more
TL;DR: Investigation of whether 19 to 20-mer α-crystallin-derived mini-chaperone peptides are antiapoptotic, and to identify their putative transporters in human fetal RPE cells found them to offer protection to hfRPE cells and inhibit caspase-3 activation.
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Identification of novel breast cancer resistance protein (BCRP) inhibitors by virtual screening.
TL;DR: The combined strategy of computational and experimental approaches in this paper has suggested potential drug candidates and thus represents an effective tool for rational identification of modulators of other proteins.
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Sodium-dependent vitamin C transporter SVCT2: expression and function in bone marrow stromal cells and in osteogenesis
Sadanand Fulzele,Paresh P. Chothe,Rajnikumar Sangani,Norman Chutkan,Mark W. Hamrick,Maryka Bhattacharyya,Puttur D. Prasad,Ibrahim Zakhary,Matthew Bowser,Carlos M. Isales,Vadivel Ganapathy +10 more
TL;DR: Data show that SVCT2 plays a vital role in the osteogenic differentiation of BMSCs and that its expression is altered under conditions associated with redox reaction, which could be relevant to bone tissue engineering and bone related diseases such as osteoporosis.
Journal ArticleDOI
Resveratrol promotes degradation of the human bile acid transporter ASBT (SLC10A2).
Paresh P. Chothe,Peter W. Swaan +1 more
TL;DR: It is demonstrated that RSV inhibits ASBT protein expression and function via a SIRT1 (sirtuin 1)-independent mechanism, and regulation of ASBT expression by RSV may have clinical relevance with regard to the observed cholesterol-lowering effects of RSV.