D
Derek M. Dykxhoorn
Researcher at University of Miami
Publications - 116
Citations - 13024
Derek M. Dykxhoorn is an academic researcher from University of Miami. The author has contributed to research in topics: RNA interference & Gene silencing. The author has an hindex of 32, co-authored 91 publications receiving 12032 citations. Previous affiliations of Derek M. Dykxhoorn include John P. Hussman Institute for Human Genomics & Boston Children's Hospital.
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Journal ArticleDOI
Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen
Abraham L. Brass,Derek M. Dykxhoorn,Yair Benita,Nan Yan,Alan Engelman,Ramnik J. Xavier,Judy Lieberman,Stephen J. Elledge +7 more
TL;DR: This article performed a large-scale small interfering RNA screen to identify host factors required by HIV-1 and identified more than 250 HIV-dependency factors (HDFs), which participate in a broad array of cellular functions and implicate new pathways in the viral life cycle.
Journal ArticleDOI
Lentivirus-delivered stable gene silencing by RNAi in primary cells.
Sheila A. Stewart,Derek M. Dykxhoorn,Deborah Palliser,Hana Mizuno,Evan Y. Yu,Dong Sung An,David M. Sabatini,Irvin S. Y. Chen,William C. Hahn,Phillip A. Sharp,Robert A. Weinberg,Carl D. Novina +11 more
TL;DR: It is demonstrated that both Moloney leukemia virus and lentivirus vector-mediated expression of RNAi can achieve effective, stable gene silencing in diverse biological systems and will assist in elucidating gene functions in numerous cell types including primary cells.
Journal ArticleDOI
Killing the messenger: short RNAs that silence gene expression
TL;DR: The application of RNA interference in mammals has the potential to allow the systematic analysis of gene expression and holds the possibility of therapeutic gene silencing, and much of the promise will depend on the recent advances in short-RNA-based silencing technologies.
Identification of host proteins required for HIV infection through a functional genomic screen
TL;DR: A large-scale small interfering RNA screen was performed to identify host factors required by HIV-1 and more than 250 HIV-dependency factors (HDFs) were identified, suggesting that viruses evolve in host cells that optimally perform the functions required for their life cycle.
Journal ArticleDOI
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
Erwei Song,Pengcheng Zhu,Sang-Kyung Lee,Dipanjan Chowdhury,Steven Kussman,Derek M. Dykxhoorn,Yi Feng,Deborah Palliser,David B. Weiner,Premlata Shankar,Wayne A. Marasco,Judy Lieberman +11 more
TL;DR: The potential for systemic, cell-type specific, antibody-mediated siRNA delivery to HIV-infected or envelope-transfected cells is demonstrated and an ErbB2 single-chain antibody fused with protamine delivered siRNAs specifically into ErBB2-expressing cancer cells.