P
Pascal Froment
Researcher at Flanders Institute for Biotechnology
Publications - 2
Citations - 327
Pascal Froment is an academic researcher from Flanders Institute for Biotechnology. The author has contributed to research in topics: Haematopoiesis & Cre recombinase. The author has an hindex of 2, co-authored 2 publications receiving 309 citations.
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Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo
Sarah Francoz,Pascal Froment,Sven Bogaerts,Sarah De Clercq,Marion M. Maetens,Gilles Doumont,Eric Bellefroid,Jean-Christophe Marine +7 more
TL;DR: A p53 knock-in allele is combined, in which p53 is silenced by a transcriptional stop element flanked by loxP sites, with the mdm2- and mdm4-null alleles, which allows Cre-mediated conditional p53 expression in tissues in vivo and cells in vitro lacking Mdm2, Mdm4, or both.
Journal ArticleDOI
Distinct roles of Mdm2 and Mdm4 in red cell production
Marion M. Maetens,Marion M. Maetens,Gilles Doumont,Sarah De Clercq,Sarah Francoz,Sarah Francoz,Pascal Froment,Eric Bellefroid,Ursula Klingmüller,Guillermina Lozano,Jean-Christophe Marine +10 more
TL;DR: The data show that Mdm2 is required for rescuing erythroid progenitors from p53-mediated apoptosis during primitive erythropoiesis, and Mdm4 only contributes to p53 regulation at a specific phase of the differentiation program.