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Eric Bellefroid
Researcher at Université libre de Bruxelles
Publications - 84
Citations - 4036
Eric Bellefroid is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Xenopus & Zinc finger. The author has an hindex of 35, co-authored 83 publications receiving 3750 citations. Previous affiliations of Eric Bellefroid include University of Göttingen & Yale University.
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The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.
TL;DR: Southern blot analysis of "zoo" blots suggests that the Krüppel-associated box is highly conserved during evolution, and Northern blot analysis shows that these genes are expressed in most adult tissues and are down-regulated during in vitro terminal differentiation of human myeloid cells.
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Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo
Sarah Francoz,Pascal Froment,Sven Bogaerts,Sarah De Clercq,Marion M. Maetens,Gilles Doumont,Eric Bellefroid,Jean-Christophe Marine +7 more
TL;DR: A p53 knock-in allele is combined, in which p53 is silenced by a transcriptional stop element flanked by loxP sites, with the mdm2- and mdm4-null alleles, which allows Cre-mediated conditional p53 expression in tissues in vivo and cells in vitro lacking Mdm2, Mdm4, or both.
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X-MyT1, a Xenopus C2HC-Type Zinc Finger Protein with a Regulatory Function in Neuronal Differentiation
Eric Bellefroid,Catherine Bourguignon,Thomas Hollemann,Qiufu Ma,David J. Anderson,Chris Kintner,Tomas Pieler +6 more
TL;DR: It is suggested that X-MyT1 is a novel, essential element in the cascade of events that allows cells to escape lateral inhibition and to enter the pathway that leads to terminal neuronal differentiation.
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The human genome contains hundreds of genes coding for finger proteins of the Krüppel type.
Eric Bellefroid,P J Lecocq,Abdellah Benhida,Dominique Poncelet,Alexandra Belayew,Joseph Martial +5 more
TL;DR: In this article, a human placenta cDNA library and a human genomic DNA library with a synthetic oligonucleotide probe corresponding to the H/C link region that connects finger loops in the multifingered Kruppel protein were compared.
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Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification
TL;DR: It is suggested that Xiro3 activation constitutes one of the earliest steps in the development of the neural plate and that it functions in the specification of a neural precursor state.