Journal ArticleDOI
Distinct roles of Mdm2 and Mdm4 in red cell production
Marion M. Maetens,Marion M. Maetens,Gilles Doumont,Sarah De Clercq,Sarah Francoz,Sarah Francoz,Pascal Froment,Eric Bellefroid,Ursula Klingmüller,Guillermina Lozano,Jean-Christophe Marine +10 more
TLDR
The data show that Mdm2 is required for rescuing erythroid progenitors from p53-mediated apoptosis during primitive erythropoiesis, and Mdm4 only contributes to p53 regulation at a specific phase of the differentiation program.About:
This article is published in Blood.The article was published on 2007-03-15. It has received 71 citations till now. The article focuses on the topics: Erythropoiesis & Haematopoiesis.read more
Citations
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Journal ArticleDOI
MDM2, MDMX and p53 in oncogenesis and cancer therapy.
TL;DR: This Review highlights the progress made and pitfalls encountered as the field continues to search for MDM-targeted antitumour agents.
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The p53 orchestra: Mdm2 and Mdmx set the tone
TL;DR: Roles for Mdm2 and Mdmx in additional cancer-related networks are considered, including Notch signaling and the epithelial-to-mesenchymal transition.
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The Mdm2–p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor
TL;DR: Growing evidence argues for p53-independent effects, as well as the remarkable possibility that Mdm2 has tumor suppressor functions in the appropriate context, which is proving to be a key player in human cancer in its own right, and thus an important target for therapeutic intervention.
Journal ArticleDOI
Mdm2-mediated ubiquitylation: p53 and beyond
TL;DR: Advances in Mdm2-mediated regulation of p53 and how the physical and functional interactions between these two proteins are regulated are evaluated and their potential implications for the development of new cancer therapeutic strategies are reviewed.
Journal ArticleDOI
MDM2 and MDM4: p53 regulators as targets in anticancer therapy
Franck Toledo,Geoffrey M. Wahl +1 more
TL;DR: Recent insights into MDM2 and MDM4 regulatory functions and their implications for the design of future p53-based anticancer strategies are highlighted.
References
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Journal ArticleDOI
Surfing the p53 network
TL;DR: The p53 tumour-suppressor gene integrates numerous signals that control cell life and death, and the disruption of p53 has severe consequences when a highly connected node in the Internet breaks down.
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Live or let die: the cell's response to p53
Karen H. Vousden,Xin Lu +1 more
TL;DR: Understanding the complex mechanisms that regulate whether or not a cell dies in response to p53 will ultimately contribute to the development of therapeutic strategies to repair the apoptotic p53 response in cancers.
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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
TL;DR: Rescue of the mdm2−/− lethality in a p53 null background suggests that a critical in vivo function of MDM2 is the negative regulation of p53 activity.
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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
TL;DR: Results suggest that a critical role of Mdm2 in development is the regulation of p53 function, and that mice deficient for both MDM2 and p53 develop normally and are viable.
Journal ArticleDOI
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
Evan Parganas,Demin Wang,Dimitrios J. Stravopodis,David J. Topham,Jean-Christophe Marine,Stephan Teglund,Elio F. Vanin,Sara Bodner,Oscar R. Colamonici,Jan M. van Deursen,Gerard Grosveld,James N. Ihle +11 more
TL;DR: Reconstitution experiments demonstrate that Jak2 is not required for the generation of lymphoid progenitors, their amplification, or functional differentiation, and plays a critical, nonredundant role in the function of a specific group of cytokines receptors.