S
Sarah Francoz
Researcher at Free University of Brussels
Publications - 14
Citations - 2242
Sarah Francoz is an academic researcher from Free University of Brussels. The author has contributed to research in topics: Mdm2 & MDMX. The author has an hindex of 11, co-authored 14 publications receiving 2063 citations. Previous affiliations of Sarah Francoz include Flanders Institute for Biotechnology & Ghent University.
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Journal ArticleDOI
Inactivation of the p53 pathway in retinoblastoma
Nikia A. Laurie,Stacy L. Donovan,Chie Schin Shih,Jiakun Zhang,Nicholas Mills,Christine E. Fuller,Amina F A S Teunisse,Suzanne Lam,Yolande F. M. Ramos,Adithi Mohan,Dianna A. Johnson,Matthew W. Wilson,Carlos Rodriguez-Galindo,Micaela Quarto,Sarah Francoz,Susan M. Mendrysa,R. Kiplin Guy,Jean-Christophe Marine,Aart G. Jochemsen,Michael A. Dyer +19 more
TL;DR: It is shown that the tumour surveillance pathway mediated by Arf, MDM2, MDMX and p53 is activated after loss of RB1 during retinogenesis, providing evidence that the p53 pathway is inactivated in retinoblastoma and that this cancer does not originate from intrinsically death-resistant cells as previously thought.
Journal ArticleDOI
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
Jean-Christophe Marine,Sarah Francoz,Marion M. Maetens,Geoffrey M. Wahl,Franck Toledo,Franck Toledo,Guillermina Lozano +6 more
TL;DR: This work presents a novel and scalable approach to gene expression engineering that allows for real-time annotation of gene expression changes in response to cancerigenicity and shows promise in finding novel and efficient treatments for cancer.
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Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity
Davide Danovi,Erik Meulmeester,Diego Pasini,Domenico Migliorini,Maria Capra,Ruth Frenk,Petra de Graaf,Sarah Francoz,Patrizia Gasparini,Alberto Gobbi,Kristian Helin,Pier Giuseppe Pelicci,Aart G. Jochemsen,Jean-Christophe Marine +13 more
TL;DR: It is shown that retrovirus-mediated Mdmx overexpression allows primary mouse embryonic fibroblast immortalization and leads to neoplastic transformation in combination with HRasV12, and this results make Hdmx a new putative drug target for cancer therapy.
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c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma
Rafael B. Blasco,Sarah Francoz,David Santamaría,Marta Cañamero,Pierre Dubus,Jean Charron,Manuela Baccarini,Mariano Barbacid +7 more
TL;DR: Results indicate that c-Raf plays a unique role in mediating K-Ras signaling and makes it a suitable target for therapeutic intervention.
Journal ArticleDOI
Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo
Sarah Francoz,Pascal Froment,Sven Bogaerts,Sarah De Clercq,Marion M. Maetens,Gilles Doumont,Eric Bellefroid,Jean-Christophe Marine +7 more
TL;DR: A p53 knock-in allele is combined, in which p53 is silenced by a transcriptional stop element flanked by loxP sites, with the mdm2- and mdm4-null alleles, which allows Cre-mediated conditional p53 expression in tissues in vivo and cells in vitro lacking Mdm2, Mdm4, or both.