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Patrice W. Miller
Researcher at University of California, Los Angeles
Publications - 8
Citations - 1528
Patrice W. Miller is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Antigen & Interleukin 10. The author has an hindex of 8, co-authored 8 publications receiving 1509 citations.
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Journal Article
Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: up-regulation of interleukin 10 and down-regulation of interleukin 12 production.
Min Huang,Marina Stolina,Sherven Sharma,Jenny T. Mao,Li Zhu,Patrice W. Miller,Jerome Wollman,Harvey R. Herschman,Steven M. Dubinett +8 more
TL;DR: The results indicate that lung tumor-derived PGE2 plays a pivotal role in promoting lymphocyte and macrophage IL-10 induction while simultaneously inhibiting macrophages IL-12 production.
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Specific Inhibition of Cyclooxygenase 2 Restores Antitumor Reactivity by Altering the Balance of IL-10 and IL-12 Synthesis
Marina Stolina,Sherven Sharma,Ying Lin,Mariam Dohadwala,Brian Gardner,Jie Luo,Li Zhu,Mitchell Kronenberg,Patrice W. Miller,Joseph Portanova,Jason C. Lee,Steven M. Dubinett +11 more
TL;DR: Abrogation of COX-2 expression promotes antitumor reactivity by restoring the balance of IL-10 and IL-12 in vivo by down-regulating production of this potent immunosuppressive cytokine.
Journal Article
T Cell-Derived IL-10 Promotes Lung Cancer Growth by Suppressing Both T Cell and APC Function
Sherven Sharma,Marina Stolina,Ying Lin,Brian Gardner,Patrice W. Miller,Mitchell Kronenberg,Steven M. Dubinett +6 more
TL;DR: It is suggested that increased levels of T cell-derived IL-10 severely impair antitumor immunity in vivo, due to defects in both T cell and APC function.
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Intratumoral Administration of Adenoviral Interleukin 7 Gene-Modified Dendritic Cells Augments Specific Antitumor Immunity and Achieves Tumor Eradication
Patrice W. Miller,Sherven Sharma,Marina Stolina,Lisa H. Butterfield,Jie Luo,Ying Lin,Mariam Dohadwala,Raj K. Batra,Lily Wu,James S. Economou,Steven M. Dubinett +10 more
TL;DR: In two murine lung cancer models adenoviral interleukin 7-transduced dendritic cells (DC-AdIL-7) were administered intratumorally, resulting in complete tumor regression, DC-Adil-7 therapy was more effective than AdIL- 7 in achieving systemic antitumor responses and enhancing immunogenicity.
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Multicomponent gene therapy vaccines for lung cancer: effective eradication of established murine tumors in vivo with interleukin-7/herpes simplex thymidine kinase-transduced autologous tumor and ex vivo activated dendritic cells
Sanjai Sharma,Patrice W. Miller,Marina Stolina,Li X. Zhu,Min Huang,R W Paul,Steven M. Dubinett +6 more
TL;DR: It is suggested that multicomponent vaccines may facilitate improved host responses by replacing host immune deficits and thus could have a role in adjuvant therapy and local control of NSCLC.