S
Steven M. Dubinett
Researcher at University of California, Los Angeles
Publications - 339
Citations - 17983
Steven M. Dubinett is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 68, co-authored 312 publications receiving 16127 citations. Previous affiliations of Steven M. Dubinett include United States Department of Veterans Affairs & West Los Angeles College.
Papers
More filters
Journal ArticleDOI
Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma.
Paulo C. Rodriguez,Claudia Hernandez,David G. Quiceno,Steven M. Dubinett,Jovanny Zabaleta,Juan B. Ochoa,Jill Gilbert,Augusto C. Ochoa +7 more
TL;DR: A new pathway of prostaglandin-induced immune dysfunction is demonstrated and a novel mechanism that can help explain the cancer prevention effects of COX-2 inhibitors is provided, which represents a clinical approach to enhance the therapeutic potential of cancer immunotherapies.
Journal ArticleDOI
Prostaglandin E2 Induces FOXP3 Gene Expression and T Regulatory Cell Function in Human CD4+ T Cells
Felicita Baratelli,Ying Lin,Li Zhu,Seok-Chul Yang,Nathalie Heuzé-Vourc'h,Gang Zeng,Karen L. Reckamp,Mariam Dohadwala,Sherven Sharma,Steven M. Dubinett +9 more
TL;DR: PGE2 enhances the in vitro inhibitory function of human purified CD4+CD25+ T reg cells and induces a regulatory phenotype in CD4-CD25− T cells, the first report indicating that PGE2 can modulate FOXP3 expression and T reg function in human lymphocytes.
Journal Article
Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: up-regulation of interleukin 10 and down-regulation of interleukin 12 production.
Min Huang,Marina Stolina,Sherven Sharma,Jenny T. Mao,Li Zhu,Patrice W. Miller,Jerome Wollman,Harvey R. Herschman,Steven M. Dubinett +8 more
TL;DR: The results indicate that lung tumor-derived PGE2 plays a pivotal role in promoting lymphocyte and macrophage IL-10 induction while simultaneously inhibiting macrophages IL-12 production.
Journal ArticleDOI
Specific Inhibition of Cyclooxygenase 2 Restores Antitumor Reactivity by Altering the Balance of IL-10 and IL-12 Synthesis
Marina Stolina,Sherven Sharma,Ying Lin,Mariam Dohadwala,Brian Gardner,Jie Luo,Li Zhu,Mitchell Kronenberg,Patrice W. Miller,Joseph Portanova,Jason C. Lee,Steven M. Dubinett +11 more
TL;DR: Abrogation of COX-2 expression promotes antitumor reactivity by restoring the balance of IL-10 and IL-12 in vivo by down-regulating production of this potent immunosuppressive cytokine.
Journal ArticleDOI
Tumor Cyclooxygenase-2/Prostaglandin E2–Dependent Promotion of FOXP3 Expression and CD4+CD25+ T Regulatory Cell Activities in Lung Cancer
Sherven Sharma,Seok-Chul Yang,Li Zhu,Karen L. Reckamp,Brian Gardner,Felicita Baratelli,Min Huang,Raj K. Batra,Steven M. Dubinett +8 more
TL;DR: In vivo inhibition of COX-2/PGE2 suppresses Treg cell activity and enhances antitumor responses, and transfer of Treg cells or administration of PGE2 to mice receiving COx-2 inhibitors reversed these effects.