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Patricia C. Come
Researcher at Harvard University
Publications - 101
Citations - 7028
Patricia C. Come is an academic researcher from Harvard University. The author has contributed to research in topics: Mitral valve & Aortic valve. The author has an hindex of 40, co-authored 101 publications receiving 6845 citations. Previous affiliations of Patricia C. Come include Dana Corporation & University of Chicago.
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Journal ArticleDOI
Alteplase versus heparin in acute pulmonary embolism: randomised trial assessing right-ventricular function and pulmonary perfusion
Samuel Z. Goldhaber,Patricia C. Come,Richard T. Lee,Eugene Braunwald,John Parker,W.D. Haire,Michael L. Feldstein,M. Miller,R. Toltzis,J.L. Smith,A.M. Taveira de Silva,A. Mogtader,T.J. McDonough +12 more
TL;DR: In this article, the authors investigated the effect of recombinant tissue plasminogen activator (alteplase, rt-PA) on pulmonary function and pulmonary perfusion in patients with acute pulmonary embolism.
Journal ArticleDOI
Left ventricular remodeling after myocardial infarction: a corollary to infarct expansion.
Raymond G. McKay,Marc A. Pfeffer,Richard C. Pasternak,John E. Markis,Patricia C. Come,Shoichiro Nakao,J. D. Alderman,James J. Ferguson,Robert D. Safian,William Grossman +9 more
TL;DR: In patients who manifest cardiac dilatation in the early convalescent period after myocardial infarction, there is remodeling of the entire left ventricle including infarct expansion of akinetic-dyskinetic segments and volume-overload hypertrophy of noninfarcted segments.
Journal ArticleDOI
Regional right ventricular dysfunction detected by echocardiography in acute pulmonary embolism.
Michael V. McConnell,Scott D. Solomon,Mamdouh E. Rayan,Patricia C. Come,Samuel Z. Goldhaber,Richard T. Lee +5 more
TL;DR: A distinct echocardiographic pattern of regional RV dysfunction, in which the apex is spared occurs in acute pulmonary embolism, should raise the level of clinical suspicion for the diagnosis of acute pulmonaryembolism.
Journal ArticleDOI
Impaired left atrial mechanical function after cardioversion: Relation to the duration of atrial fibrillation
Warren J. Manning,David I. Silverman,Sarah E. Katz,Marilyn F. Riley,Patricia C. Come,Rosalie M. Doherty,Jiyl T. Munson,Pamela S. Douglas +7 more
TL;DR: Recovery of left atrial mechanical function is related to the duration of atrial fibrillation before cardioversion, and these findings have important implications for assessing the early hemodynamic benefit of successful cardioversion.
Journal ArticleDOI
Pulsed Doppler evaluation of atrial mechanical function after electrical cardioversion of atrial fibrillation
TL;DR: To examine the time course of recovery of left atrial mechanical function, serial two-dimensional, M-mode and transmitral pulsed Doppler echocardiographic studies were performed in patients after elective direct current cardioversion of atrial fibrillation.